Strategies for p53 Reactivation in Human Sarcoma

HuppT.R.; HaywardR.L.; VojtesekB.

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Strategies for p53 Reactivation in Human Sarcoma

机译：人肉瘤中p53激活的策略

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Emerging strategies in cancer therapeutics link the genomic mutational and proteomic landscape, allowing intelligent reasoning on target selection. In this issue of Cancer Cell, Piccinin and colleagues use this approach to demonstrate that the mesenchymal protein Twist1 inhibits p53, providing a novel target for reactivation of p53 in human sarcoma.

机译：癌症治疗学中的新兴策略将基因组突变和蛋白质组学联系在一起，从而可以智能地进行目标选择。在本期《癌细胞》杂志中，Piccinin及其同事使用这种方法来证明间充质蛋白Twist1抑制p53，为人类肉瘤中p53的重新激活提供了新的靶点。

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《Cancer Cell》 |2012年第3期|共3页
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HuppT.R.; HaywardR.L.; VojtesekB.;
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正文语种 eng
中图分类肿瘤学;
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1. Strategies for p53 Reactivation in Human Sarcoma [J] . HuppT.R., HaywardR.L., VojtesekB. Cancer Cell . 2012,第3期

机译：人肉瘤中p53激活的策略
2. CD99 Triggering in Ewing Sarcoma Delivers a Lethal Signal through p53 Pathway Reactivation and Cooperates with Doxorubicin [J] . Guerzoni Clara, Fiori Valentina, Terracciano Mario, Clinical cancer research: an official journal of the American Association for Cancer Research . 2015,第1期

机译：CD99触发在EWING SARCOMA中通过P53途径重新激活和与多柔比星配合的致命信号提供致命的信号
3. Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53 [J] . VanDerEntW., JochemsenA.G., TeunisseA.F.A.S., Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland . 2014,第4期

机译：通过破坏EWSR1-FLI1转录活性和激活p53来抑制尤文肉瘤
4. Investigating the details of oncogenic mutant p53 reactivation using FT-ICR Mass Spectrometry. [C] . David J. Clarke, Jenna Scotcher, Ted Hupp, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：使用FT-ICR质谱法研究致癌突变体P53重新激活细节。
5. K-bZIP of Kaposi's sarcoma -associated herpesvirus; ablation of expression and genomewide analysis of viral promoter recruitment and transactivation potential in reactivation from latency [D] . Ellison, Thomas James 2008

机译：卡波西氏肉瘤相关疱疹病毒的K-bZIP；从潜伏期重新激活中病毒启动子募集和反式激活的表达消融和全基因组分析
6. Variability in functional p53 reactivation by PRIMA-1Met/APR-246 in Ewing sarcoma [O] . D N T Aryee, S Niedan, J Ban, 2013

机译：PRIMA-1Met / APR-246在尤因肉瘤中功能性p53激活的变化
7. Strategies for p53 Reactivation in Human Sarcoma [O] . Hupp Ted R., Hayward Richard L., Vojtesek Borek 2012

机译：人肉瘤中p53激活的策略

Strategies for p53 Reactivation in Human Sarcoma

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