BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia

CrispinoJ.D.; LeBeauM.M.

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BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia

机译：BMP遇到AML：一种新型融合基因诱导BMP信号促进小儿急性白血病

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In this issue of Cancer Cell, Gruber et al. report that a significant proportion of children with acute megakaryoblastic leukemia acquire a translocation that confers enhanced BMP signaling and promotes self-renewal of hematopoietic progenitors. This study presents novel therapeutic targets that may lead to improved therapies for this aggressive leukemia.

机译：在本期《癌细胞》中，Gruber等人。报告指出，相当一部分患有急性巨核细胞白血病的儿童易位，可增强BMP信号传导并促进造血祖细胞的自我更新。这项研究提出了新的治疗靶标，可能会导致这种侵袭性白血病的治疗方法得到改善。

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《Cancer Cell》 |2012年第5期|共2页
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CrispinoJ.D.; LeBeauM.M.;
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正文语种 eng
中图分类肿瘤学;
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1. BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia [J] . CrispinoJ.D., LeBeauM.M. Cancer Cell . 2012,第5期

机译：BMP遇到AML：一种新型融合基因诱导BMP信号促进小儿急性白血病
2. A novel TEL-AML1 fusion transcript involving the pro-apoptotic gene BCL-G in pediatric precursor B acute lymphoblastic leukemia [J] . M Abdelhaleem, Q Yi, K Beimnet, Leukemia . 2006,第7期

机译：小儿前体B急性淋巴细胞白血病中涉及促凋亡基因BCL-G的新型TEL-AML1融合转录本
3. Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey. [J] . Ozbek U, Sirma S, Agaoglu L, Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology . 2003,第3期

机译：TEL-AML1融合基因在土耳其小儿急性淋巴细胞白血病中的预后意义。
4. Effectiveness of water and nutrient BMPs to meet regulatory requirements for commercial strawberry production in Florida, USA [C] . Craig D. Stanley World Congress of Soil Science . 2011

机译：水和营养BMP符合美国商业草莓生产监管要求的效力
5. Molecular and embryological mechanisms of neural crest induction: The role of BMP signaling and underlying mesoderm in Danio rerio. [D] . Ragland, Jared William. 2004

机译：神经c诱导的分子和胚胎机制：BMP信号传导和下胚层在里约热内卢的作用。
6. BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia [O] . John D. Crispino, Michelle M. Le Beau -1

机译：Bmp满足amL：Bmp的由新的融合基因信令感应促进小儿急性白血病
7. BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia [O] . Crispino John D., Le Beau Michelle M. 2012

机译：BMP遇到AML：通过新型融合基因诱导BMP信号促进小儿急性白血病

BMP Meets AML: Induction of BMP Signaling by a Novel Fusion Gene Promotes Pediatric Acute Leukemia

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