• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cancer Cell >Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas
【24h】

Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas

机译：HDAC3和EZH2协同沉默MYC介导的miR-29作为侵袭性B细胞淋巴瘤中组蛋白修饰的治疗靶标

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3, and EZH2 in mantle cell lymphoma and other MYC-associated lymphomas. We demonstrate that miR-29 is repressed by MYC through a corepressor complex with HDAC3 and EZH2. MYC contributes to EZH2 upregulation via repression of the EZH2 targeting miR-26a, and EZH2 induces MYC via inhibition of the MYC targeting miR-494 to create positive feedback. Combined inhibition of HDAC3 and EZH2 cooperatively disrupted the MYC-EZH2-miR-29 axis, resulting in restoration of miR-29 expression, downregulation of miR-29-targeted genes, and lymphoma growth suppression in vitro and in vivo. These findings define a MYC-mediated miRNA repression mechanism, shed light on MYC lymphomagenesis mechanisms, and reveal promising therapeutic targets for aggressive B-cell malignancies.
机译：我们调查了套细胞淋巴瘤和其他与MYC相关的淋巴瘤中MYC，HDAC3和EZH2对miR-29的转录和表观遗传抑制。我们证明，通过与HDAC3和EZH2的corepressor复合体，MYC可以抑制miR-29。 MYC通过抑制靶向EZH2的miR-26a促进EZH2上调，而EZH2通过抑制靶向MYR-494的MYC诱导MYC产生正反馈。联合抑制HDAC3和EZH2协同破坏了MYC-EZH2-miR-29轴，导致miR-29表达恢复，miR-29靶向基因的下调以及体内外淋巴瘤的生长抑制。这些发现定义了MYC介导的miRNA抑制机制，阐明了MYC淋巴瘤的发生机制，并揭示了侵略性B细胞恶性肿瘤的有希望的治疗靶标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号