Epigenetic Therapy Leaps Ahead with Specific Targeting of EZH2

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Epigenetic Therapy Leaps Ahead with Specific Targeting of EZH2

机译：表观遗传学疗法以EZH2为靶标而飞跃发展

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The Polycomb epigenetic silencing protein EZH2 is affected by gain-of-function somatic mutations in B cell lymphomas. Two recent reports describe the development of highly selective EZH2 inhibitors and reveal mutant EZH2 as playing an essential role in maintaining lymphoma proliferation. EZH2 inhibitors are thus a promising new targeted therapy for lymphoma.

机译：Polycomb表观遗传沉默蛋白EZH2受B细胞淋巴瘤功能获得性体细胞突变的影响。最近的两项报道描述了高度选择性的EZH2抑制剂的开发，并揭示了突变型EZH2在维持淋巴瘤增殖中起着至关重要的作用。因此，EZH2抑制剂是一种有希望的针对淋巴瘤的新型靶向疗法。

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《Cancer Cell》 |2012年第5期|共2页
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MelnickA.;
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正文语种 eng
中图分类肿瘤学;
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1. Epigenetic Therapy Leaps Ahead with Specific Targeting of EZH2 [J] . MelnickA. Cancer Cell . 2012,第5期

机译：表观遗传学疗法以EZH2为靶标而飞跃发展
2. Epigenetic Targeting with EZH2 and HDAC Inhibitors Is Synergistic in EZH2 Deregulated Lymphomas [J] . Lue Jennifer Kimberly, Prabhu Sathyen A., Liu Yuxuan, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：用EzH2和HDAC抑制剂靶向靶向靶向靶向抑制剂在EZH2 Deregutated淋巴瘤中是协同的
3. VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy [J] . RiquelmeE., SuraokarM., BehrensC., Clinical cancer research: an official journal of the American Association for Cancer Research . 2014,第14期

机译：VEGF / VEGFR-2上调肺腺癌细胞中EZH2的表达，EZH2的消耗增强对铂类和VEGFR-2靶向治疗的反应
4. Exploring the role of EZH2 (PRC2) as epigenetic target [C] . Imlimaong Aier, Utkarsh Raj 2016 International Conference on Bioinformatics and Systems Biology . 2016

机译：探索EZH2（PRC2）作为表观遗传靶的作用
5. β Cell Replacement Therapy: A Novel Application for Targeted Epigenetic Editing [D] . Ou, Kristy. 2018

机译：β细胞替代疗法：靶向表观遗传编辑的新申请
6. Epigenetic Therapy Leaps Ahead with Specific Targeting of EZH2 [O] . Ari Melnick -1

机译：表观治疗又迈进了一步与EZH2的特异性靶向
7. Epigenetic Therapy Leaps Ahead with Specific Targeting of EZH2 [O] . Melnick Ari 2012

机译：表观遗传学疗法以EZH2为靶标而飞跃发展
8. Epigenetic Therapy of Hematopoietic Malignancies: Novel Approaches for Tissue-Specific and Global Inhibition of EZH2 Enzymatic Activities. [R] . Wang, G. 2017

机译：造血系统恶性肿瘤的表观遗传治疗：组织特异性和全局抑制EZH2酶活性的新方法。

Epigenetic Therapy Leaps Ahead with Specific Targeting of EZH2

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