The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.

Yang Wang; Dan Chen; Haili Qian; Yihsuan S Tsai; Shujuan Shao; Quentin Liu; Daniel Dominguez; Zefeng Wang

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The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.

机译：剪接因子RBM4控制细胞凋亡，增殖和迁移，以抑制肿瘤进展。

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Splicing dysregulation is one of the molecular hallmarks of cancer. However, the underlying molecular mechanisms remain poorly defined. Here we report that the splicing factor RBM4 suppresses proliferation and migration of various cancer cells by specifically controlling cancer-related splicing. Particularly, RBM4 regulates Bcl-x splicing to induce apoptosis, and coexpression of Bcl-xL partially reverses the RBM4-mediated tumor suppression. Moreover, RBM4 antagonizes an oncogenic splicing factor, SRSF1, to inhibit mTOR activation. Strikingly, RBM4 expression is decreased dramatically in cancer patients, and the RBM4 level correlates positively with improved survival. In addition to providing mechanistic insights of cancer-related splicing dysregulation, this study establishes RBM4 as a tumor suppressor with therapeutic potential and clinical values as a prognostic factor.

机译：剪接失调是癌症的分子标志之一。但是，潜在的分子机制仍然不清楚。在这里我们报告剪接因子RBM4通过专门控制癌症相关的剪接抑制各种癌细胞的增殖和迁移。特别地，RBM4调节Bcl-x剪接以诱导凋亡，并且Bcl-xL的共表达部分逆转了RBM4介导的肿瘤抑制。此外，RBM4拮抗致癌剪接因子SRSF1，以抑制mTOR激活。令人惊讶的是，在癌症患者中，RBM4的表达显着降低，并且RBM4的水平与存活率的提高呈正相关。除了提供与癌症有关的剪接失调的机理见解外，本研究还建立了RBM4作为肿瘤抑制因子，具有治疗潜力和临床价值作为预后因素。

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《Cancer Cell》 |2014年第3期|共16页
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Yang Wang; Dan Chen; Haili Qian; Yihsuan S Tsai; Shujuan Shao; Quentin Liu; Daniel Dominguez; Zefeng Wang;
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正文语种 eng
中图分类肿瘤学;
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1. The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression. [J] . Yang Wang, Dan Chen, Haili Qian, Cancer Cell . 2014,第3期

机译：剪接因子RBM4控制细胞凋亡，增殖和迁移，以抑制肿瘤进展。
2. MiR-140-5p and miR-92a-3p suppress the cell proliferation, migration and invasion and promoted apoptosis in Wilms’ tumor by targeting FRS2 [J] . J.-L. Li, P. Luo European review for medical and pharmacological sciences. . 2020,第1期

机译：miR-140-5p和mir-92a-3p通过靶向frs2抑制细胞增殖，迁移和侵袭，促进了Wilms肿瘤的凋亡
3. Novel C-4 Heteroaryl 13-cis-Retinamide Mnk/AR Degrading Agents Inhibit Cell Proliferation and Migration and Induce Apoptosis in Human Breast and Prostate Cancer Cells and Suppress Growth of MDA-MB-231 Human Breast and CWR22Rv1 Human Prostate Tumor Xenografts in Mice [J] . Mbatia Hannah W., Ramalingam Senthilmurugan, Ramamurthy Vidya P., Journal of Medicinal Chemistry . 2015,第4期

机译：新型C-4杂芳基13-顺式视黄酰胺Mnk / AR降解剂抑制人乳腺癌和前列腺癌细胞的增殖和迁移并诱导其凋亡，并抑制MDA-MB-231人乳腺癌和CWR22Rv1人前列腺肿瘤异种移植物的生长。
4. Effect of Molecular Size of PEGylated tumor necrosis factor factor-related apoptosis apoptosis-inducing ligand(TRAIL) : T The Biological Activity and he Stability [C] . Tae Hyung Kim, Su Young Chae, Seung Min Byun, Annual meeting exposition of the Controlled Release Society . 2009

机译：PEG化肿瘤坏死因子相关细胞凋亡诱导配体（TRAIL）分子大小的影响生物学活性和稳定性
5. Dietary isothiocyanates suppress microtubule dynamic instability in association with mitotic arrest and inhibition of tumor cell proliferation. [D] . Azarenko, Olga. 2009

机译：饮食中的异硫氰酸盐抑制与有丝分裂停滞和抑制肿瘤细胞增殖相关的微管动态不稳定性。
6. The splicing factor RBM4 controls apoptosis proliferation and migration to suppress tumor progression [O] . Yang Wang, Dan Chen, Haili Qian, -1

机译：剪接因子RBM4控制细胞凋亡增殖和迁移以抑制肿瘤进展
7. The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression [O] . Wang Yang, Chen Dan, Qian Haili, 2014

机译：剪接因子RBM4控制细胞凋亡，增殖和迁移，以抑制肿瘤进展。
8. Mechanisms of Altered Control of Proliferation by Cyclic Amp/Protein Kinase A During Mammary Tumor Progression. [R] . Imagawa, W. 2001

机译：乳腺肿瘤进展过程中循环放大器/蛋白激酶a增殖控制机制的研究。

The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.

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