Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53

Bohlman Stephen; Manfredi James J.

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Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53

机译：Mdm2-RNA相互作用作为癌症治疗的目标：并非全部与p53有关

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In this issue of Cancer Cell, Gu et al. characterize small molecules that inhibit the interaction of Mdm2 with the mRNA that encodes the anti-apoptotic XIAP, simultaneously decreasing expression of both proteins. This represents a novel approach that has relevance in tumor cells independent of p53 status.

机译：在本期《癌细胞》中，Gu等人。表征抑制Mdm2与编码抗凋亡XIAP的mRNA相互作用的小分子，同时降低两种蛋白质的表达。这代表了一种新颖的方法，与p53状态无关，在肿瘤细胞中具有相关性。

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《Cancer Cell》 |2016年第4期|共2页
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Bohlman Stephen; Manfredi James J.;
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正文语种 eng
中图分类肿瘤学;
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1. Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53 [J] . Bohlman Stephen, Manfredi James J. Cancer Cell . 2016,第4期

机译：Mdm2-RNA相互作用作为癌症治疗的目标：并非全部与p53有关
2. Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy. [J] . Lu WJ, Lee NP, Kaul SC, Cell death and differentiation . 2011,第6期

机译：癌细胞中的Mortalin-p53相互作用是压力依赖性的，并构成癌症治疗的选择性靶标。
3. The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs [J] . Slattery Martha L., Mullany Lila E., Wolff Roger K., Genomics . 2019,第4期

机译：P53信号通路和结直肠癌：下游P53靶基因与miRNA之间的相互作用
4. New p53-targeted Cancer Therapies Combined with Gene or ChemicalChaperone Therapy [C] . The 3rd Asian congress on hyperthermic oncology and the 9th Chineses symposium on hyperthermic oncology . 2002

机译：结合基因或化学伴侣疗法的新型针对p53的癌症疗法
5. Exploring p53 protein -protein interactions as targets for chemotherapy. [D] . Heo, Soyoung. 2009

机译：探索p53蛋白-蛋白相互作用作为化疗靶标。
6. The Role of Tumor Protein 53 Mutations in Common Human Cancers and Targeting the Murine Double Minute 2–P53 Interaction for Cancer Therapy [O] . Tayebeh Hamzehloie, Majid Mojarrad, Mohammad Hasanzadeh_Nazarabadi, 2012

机译：肿瘤蛋白53突变在普通人类癌症中的作用和靶向小鼠双分钟2-P53相互作用的癌症治疗。
7. Mdm2-RNA Interactions as a Target for Cancer Therapy: It’s Not All About p53 [O] . Stephen Bohlman, James J. Manfredi 2016

机译：MDM2-RNA相互作用作为癌症治疗的靶标：并非所有关于P53

Mdm2-RNA Interactions as a Target for Cancer Therapy: It's Not All About p53

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