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首页> 外文期刊>Cancer Cell >A Preclinical Model for ER alpha-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response
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A Preclinical Model for ER alpha-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response

机译：ERα阳性乳腺癌的临床前模型指出上皮微环境是发光表型和激素反应的决定因素。

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摘要

Seventy-five percent of breast cancers are estrogen receptor a positive ( ER+). Research on these tumors is hampered by lack of adequate in vivo models; cell line xenografts require non-physiological hormone supplements, and patient-derived xenografts (PDXs) are hard to establish. We show that the traditional grafting of ER+ tumor cells into mammary fat pads induces TGF beta/SLUG signaling and basal differentiation when they require low SLUG levels to grow in vivo. Grafting into the milk ducts suppresses SLUG; ER+ tumor cells develop, like their clinical counterparts, in the presence of physiological hormone levels. Intraductal ER+ PDXs are retransplantable, predictive, and appear genomically stable. The model provides opportunities for translational research and the study of physiologically relevant hormone action in breast carcinogenesis.
机译：百分之七十五的乳腺癌是雌激素受体阳性（ER +）。对这些肿瘤的研究由于缺乏适当的体内模型而受到阻碍。细胞系异种移植物需要非生理激素补充剂，患者来源的异种移植物（PDXs）很难建立。我们显示传统的ER +肿瘤细胞嫁接到乳腺脂肪垫诱导TGFβ/ SLUG信号和基础分化时，他们需要低SLUG水平才能在体内生长。移植到牛奶导管中可抑制SL。 ER +肿瘤细胞会像其临床对应物一样在生理激素水平存在下发育。导管内ER + PDX具有可再移植性，预测性和基因组稳定性。该模型为转化研究和乳腺癌致癌过程中生理相关激素作用的研究提供了机会。

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