'Dub'bing a tumor suppressor pathway.

Niedzwiedz W; Patel KJ

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'Dub'bing a tumor suppressor pathway.

机译：“复制”肿瘤抑制途径。

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The autosomal recessive disease Fanconi anemia (FA) causes bone marrow failure and a hugely increased propensity to develop cancer. Cells from FA patients are prone to chromosome breakage, indicating that FA gene products are required to ensure genomic integrity. Most of the identified FA proteins are components of a nuclear complex whose principal function is to activate FANCD2 by monoubiquitination. Monoubiquitinated FANCD2 accumulates at sites of genome damage, where it probably functions to facilitate DNA repair. A recent paper in Molecular Cell (Nijmanet al., 2005) reports the identification of an enzyme that is responsible for regulating the FA pathway by deactivating FANCD2.

机译：常染色体隐性遗传疾病Fanconi贫血（FA）会导致骨髓衰竭，并大大增加患癌的可能性。 FA患者的细胞容易发生染色体断裂，表明需要FA基因产物来确保基因组完整性。大多数已鉴定的FA蛋白是核复合物的组成部分，其主要功能是通过单泛素化激活FANCD2。单泛素化的FANCD2聚集在基因组损伤的部位，在该部位可能起到促进DNA修复的作用。分子细胞（Nijmanet等人，2005）上的最新论文报道了一种通过灭活FANCD2来调节FA途径的酶的鉴定。

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《Cancer Cell》 |2005年第2期|共2页
作者
Niedzwiedz W; Patel KJ;
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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Neoplasms; Cells; activate; Personal failure; 肿瘤; 细胞;

机译：Neoplasms;Cells;activate;Personal failure;肿瘤;细胞;

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专利

1. "Dub"bing a tumor suppressor pathway. [J] . Niedzwiedz W, Patel KJ Cancer Cell . 2005,第2期

机译：“复制”肿瘤抑制途径。
2. Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription [J] . T P Cash, J J Gruber, T R Hartman, Oncogene . 2011,第22期

机译：由于异常的TGFβ介导的转录，失去Birt–Hogg–Dubé肿瘤抑制因子会导致凋亡抵抗
3. Loss of the Birt|[ndash]|Hogg|[ndash]|Dub|[eacute]| tumor suppressor results in apoptotic resistance due to aberrant TGF|[beta]|-mediated transcription [J] . T P Cash, J J Gruber, T R Hartman, Oncogene . 2011,第22期

机译：失去肥大| [ndash] | hogg | [ndash] | dub | [eacute] |由于异常TGF |介导的转录，肿瘤抑制导致凋亡抗性
4. Oncogenes and tumor suppressor genes in murine tumors induced by neutron- or gamma-irradiation in utero [C] . Sara Antal, K. Lumniczky, J. Palfalvi, International Symposium of Radiation and Homeostasis . 2002

机译：子宫中子或γ-辐照诱导的鼠肿瘤中的癌肠和肿瘤抑制基因
5. SnoN is a stress transducer that is able to function as a tumor suppressor in vivo by interacting with the PML-p53 pathway. [D] . Pan, Deng. 2010

机译：SnoN是一种应力传感器，能够通过与PML-p53途径相互作用而在体内充当肿瘤抑制物。
6. Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription [O] . T P Cash, J J Gruber, T R Hartman, -1

机译：由于异常的TGFβ介导的转录失去Birt–Hogg–Dubé抑癌剂会导致凋亡抵抗
7. “Dub”bing a tumor suppressor pathway [O] . Niedzwiedz Wojciech, Patel Ketan J. 2005

机译：“复制”肿瘤抑制途径
8. Therapeutic Insights From a Novel Breast Tumor Suppressor Pathway. [R] . Colicelli, J. J. 2005

机译：新型乳腺肿瘤抑制途径的治疗见解。

'Dub'bing a tumor suppressor pathway.

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