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首页> 外文期刊>Microbial drug resistance: MDR : Mechanisms, epidemiology, and disease >Prevalence of the Internalization-Associated Gene prtF1 in a Bacterial Population of Streptococcus pyogenes Isolated from Children with Acute Pharyngotonsillitis before and after Antibiotic Therapy.
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Prevalence of the Internalization-Associated Gene prtF1 in a Bacterial Population of Streptococcus pyogenes Isolated from Children with Acute Pharyngotonsillitis before and after Antibiotic Therapy.

机译：抗生素治疗前后从化脓性链球菌炎患儿分离的化脓性链球菌细菌种群中内化相关基因prtF1的患病率。

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The prevalence of the internalization-associated prtF1 gene was studied in 837 isolates of Streptococcus pyogenes obtained from 713 pediatric patients presenting with acute pharyngotonsillitis before and after antibiotic therapy. Its association with macrolide resistance and with bacteriological treatment failure was determined. The bacterial population isolated from baseline pharyngeal swabs showed an overall prtF1 positivity rate of 33%. A higher prtF1 positivity was found among erythromycin-resistant strains (45%) showing, however, marked differences between the inducible (iMLS), constitutive (cMLS), and efflux pump (M) resistance phenotypes. The prevalence was statistically higher (p < 0.001) in strains belonging to iMLS (84%) and cMLS (67%) phenotypes as compared to the M phenotype (15%). Interestingly, the prevalence of the prtF1 gene was significantly lower (p = 0.04) in strains belonging to M resistance phenotype as compared to erythromycin-susceptible strains (28%). Failed bacterial eradication was demonstrated in 124 patients. The prtF1 positivity rate remained unchanged in strains isolated before and after therapy in patients treated with macrolides (9/54). On the other hand, the positivity rate for the prtF1 gene was significantly higher (p = 0.015) in strains isolated after therapy with beta-lactams (21/70) as compared to baseline isolates (6/70), indicating a differential selection imposed on the organism by these agents. Finally, a high overall eradication rate (88%) of prtF1-positive isolates, belonging to both the erythromycin-susceptible and -resistant phenotypes, was demonstrated following macrolide treatment.
机译：在从713例患有急性咽喉炎的小儿患者中获得的837例化脓性链球菌菌株中，研究了与内化相关的prtF1基因的患病率。确定了其与大环内酯耐药性和细菌治疗失败的关联。从基线咽拭子分离出的细菌群体显示prtF1总体阳性率为33％。在抗红霉素的菌株中发现较高的prtF1阳性率（45％），显示出诱导型（iMLS），组成型（cMLS）和外排泵（M）耐药表型之间存在显着差异。与M表型（15％）相比，属于iMLS表型（84％）和cMLS表型（67％）的菌株的患病率在统计学上更高（p <0.001）。有趣的是，与易感红霉素的菌株（28％）相比，属于M抗性表型的菌株中prtF1基因的患病率显着降低（p = 0.04）。在124例患者中证明细菌清除失败。在接受大环内酯类药物治疗的患者中，治疗前后分离的菌株的prtF1阳性率保持不变（9/54）。另一方面，与基线分离株（6/70）相比，在用β-内酰胺（21/70）治疗后分离出的菌株中，prtF1基因的阳性率显着更高（p = 0.015）。这些试剂对生物体的作用。最后，在大环内酯类药物治疗后，证实了同时属于红霉素敏感性和抗性表型的prtF1阳性分离株的总体清除率为88％。

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