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首页> 外文期刊>Microbial Pathogenesis >Temperature dependent siderophore production in Vibrio salmonicida
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Temperature dependent siderophore production in Vibrio salmonicida

机译：鲑鱼弧菌的温度依赖性铁载体生产

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摘要

Vibrio salmonicida is the causative agent of cold water vibriosis, a haemorrhagic septicaemia of Atlantic salmon (Salmo salar). The disease is observed only at low water temperatures and not normally above 10 degreesC. Siderophore production and iron regulated outer membrane protein expression was studied at various temperatures. Although in iron-limited media optimal cell growth was identified at 12 degreesC, significant quantities of a single hydroxamate siderophore were produced only at 10 degreesC or below. Dependent on inoculant size, good growth without significant siderophore production was also observed in iron-limited media at temperatures above and below 10 degreesC. It is therefore likely that V salmonicida also possesses one or more non-siderophore based iron assimilation systems. Expression of high molecular weight iron-regulated outer membrane proteins appeared to be suppressed at 15 degreesC compared to expression at 6 and 10 degreesC. It is proposed that temperature sensitive iron sequestration may constitute a significant virulence factor in V salmonicida and may have implications for vaccine manufacture.
机译：鲑鱼弧菌是冷水弧菌病的病原体，是大西洋鲑鱼（Salmo salar）的出血性败血病。该病仅在低水温下观察到，通常不高于10摄氏度。在不同温度下研究了铁载体的产生和铁调节的外膜蛋白表达。尽管在铁受限的培养基中可以确定最佳的细胞生长是在12摄氏度，但仅在10摄氏度或更低的温度下会产生大量的单一异羟肟酸酯铁载体。根据接种量的大小，在温度高于和低于10摄氏度的铁限制培养基中也观察到了良好的生长而没有明显的铁载体生成。因此，很有可能沙门氏菌也拥有一种或多种基于非铁载体的铁同化系统。与在6和10℃下的表达相比，在15℃下高分子量铁调节的外膜蛋白的表达似乎被抑制。有人提出，温度敏感的铁螯合可能构成鲑鱼弧菌的重要毒力因子，并可能对疫苗生产产生影响。

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