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首页> 外文期刊>Microbial Pathogenesis >Interaction of coagulase-negative Staphylococcus species with bovine mammary epithelial cells
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Interaction of coagulase-negative Staphylococcus species with bovine mammary epithelial cells

机译：凝固酶阴性葡萄球菌与牛乳腺上皮细胞的相互作用

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摘要

Three coagulase-negative Staphylococcus species (CNS) (Staphylococcus epidermidis, Staphylococcus xylosus and Staphylococcus hyicus), from the milk of cows with mastitis, were used to evaluate adherence to and internalization by bovine mammary epithelia[ cells, and to investigate involvement of host cell signal transduction and host cell cytoskeleton rearrangement on internalization of CNS. S. xylosus showed highest adherence and internalization values of the species evaluated. Host cell cytoskeleton polymerization and protein kinase (PK) phosphorylation were required for internalization of CNS. Both protein kinase C (PKC) and tyrosine kinase (TPK) pathways were involved, but internalization of S. xylosus occurred preferentially through epidermal growth factor TPK activity. S. epidermidis and S. hyicus seemed to exploit other TPK pathways. Results of this study showed that S. xylosus, S. hyicus and S. epidermidis were able to adhere and internalize bovine mammary cells in a process that appeared to be receptor(s) mediated and exploited host signal transduction and cytoskeleton to induce an uptake signal.
机译：来自乳腺炎奶牛的三种凝固酶阴性葡萄球菌（CNS）（表皮葡萄球菌，木糖葡萄球菌和hyicus葡萄球菌）被用于评估对牛乳腺上皮细胞的粘附和内在化，并研究宿主细胞的参与CNS内在化的信号转导和宿主细胞骨架的重排。木糖链霉菌显示出所评估物种的最高粘附性和内在化值。中枢神经系统的内在化需要宿主细胞的骨架聚合和蛋白激酶（PK）磷酸化。涉及蛋白激酶C（PKC）和酪氨酸激酶（TPK）途径，但木糖链球菌的内在化优先通过表皮生长因子TPK活性发生。表皮葡萄球菌和葡萄球菌似乎利用了其他TPK途径。这项研究的结果表明，木糖链霉菌，hyicus和表皮葡萄球菌能够粘附和内化牛乳腺细胞，这一过程似乎是受体介导的，并利用宿主信号转导和细胞骨架诱导摄取信号。 。

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