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首页> 外文期刊>Methods and findings in experimental and clinical pharmacology >A prospective study on the pattern of medication use for schizophrenia in the outpatient pharmacy department, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia.
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A prospective study on the pattern of medication use for schizophrenia in the outpatient pharmacy department, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia.

机译：马来西亚雪兰莪州腾库安普安拉希玛医院门诊药房的精神分裂症用药模式的前瞻性研究。

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Schizophrenia is a chronic psychiatric disorder and pharmacotherapy plays a major role in its management. The 1950s and early 1960s saw milestones in the introduction of psychotropic drugs in clinical practice. A review of drug prescriptions in different settings provides an insight into the pattern of drug use, identifies drug-related problems and may be used to compare recommended guidelines with actual practice. This effort led to the evaluation of the drug prescribing pattern of antipsychotics in patients attending the psychiatric clinic at a government hospital. The data from 371 antipsychotic medication prescriptions that included 200 prescriptions for schizophrenia were collected during one month (1rst-31rst August 2008) at the outpatient pharmacy department. The mean age of patients was 35.0 years (SD = 1.131), with a male to female ratio of 2:1. The most widely used oral antipsychotic was haloperidol (16.3%) while the most common depot preparation prescribed was zuclopenthixol decanoate (8.8%). The daily dose of the average antipsychotic prescribed in this clinic was 342.06 mg equivalent of chlorpromazine. There was no relation between the doses received and ethnicity of the patient (Malay, Chinese or Indian). However, there was a significant relationship between the prescribed dose and patient age (P < 0.042). Nearly 32% of the schizophrenia patients were prescribed with atypical antipsychotics such as olanzapine (10.8%), risperidone (10.0%), quetiapine (7.6%) and clozapine (3.2%). Monotherapy was given to 73.0% of the schizophrenia patients. The majority of patients also received antidepressants. To conclude, this study gave evidence that physicians had a strong preference for monotherapy with conventional antipsychotic drugs while the use of atypical drugs was less prevalent.
机译：精神分裂症是一种慢性精神病，药物治疗在其管理中起主要作用。 1950年代和1960年代初，在临床实践中引入精神药物具有里程碑式的意义。审查不同环境中的药物处方可深入了解药物使用的模式，识别与药物有关的问题，并可用于将推荐的指南与实际操作进行比较。这项工作导致对在政府医院的精神科门诊就诊的抗精神病药的药物处方模式进行了评估。在一个月（2008年8月1日至31日）的门诊药房收集了371份抗精神病药物处方的数据，其中包括200份精神分裂症的处方。患者的平均年龄为35.0岁（SD = 1.131），男女之比为2：1。口服抗精神病药使用最广泛的是氟哌啶醇（16.3％），而处方中最常见的长效制剂是癸酸戊哌西醇（8.8％）。该诊所规定的平均抗精神病药物的日剂量为342,06 mg等效氯丙嗪。所接受的剂量与患者的种族（马来语，中文或印度语）之间没有关系。但是，处方剂量与患者年龄之间存在显着关系（P <0.042）。将近32％的精神分裂症患者开具非典型抗精神病药，如奥氮平（10.8％），利培酮（10.0％），喹硫平（7.6％）和氯氮平（3.2％）。 73.0％的精神分裂症患者接受了单一疗法。大多数患者也接受了抗抑郁药。总而言之，这项研究提供了证据，表明医师对使用常规抗精神病药物的单一疗法有强烈的偏爱，而使用非典型药物则较不普遍。

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