Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.

Xie K; Abbruzzese JL

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Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.

机译：发育生物学告知癌症：刺猬信号通路在上消化道癌症中的新兴作用。

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The hedgehog (Hh) signaling pathway plays many roles in invertebrate and vertebrate development. For example, specific inhibition of sonic Hh expression is critical during early stages of pancreas organogenesis, but an active Hh pathway appears to be required for maintenance of adult endocrine functions. Mutational inactivation of the Hh pathway has been demonstrated in human malignancies of the skin, cerebellum, and skeletal muscle. Now, two papers implicate aberrant Hh signaling in human upper gastrointestinal cancers including those developing from the esophagus, stomach, biliary tract, and pancreas.

机译：刺猬（Hh）信号通路在无脊椎动物和脊椎动物的发育中起许多作用。例如，在胰腺器官发生的早期阶段，声音Hh表达的特异性抑制是至关重要的，但是维持成人内分泌功能似乎需要活跃的Hh途径。 Hh途径的突变失活已在人皮肤，小脑和骨骼肌的恶性肿瘤中得到证实。现在，有两篇论文暗示了Hh信号在人类上消化道癌中的发生，包括从食道，胃，胆道和胰腺发展而来的癌。

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《Cancer Cell》 |2003年第4期|共3页
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Xie K; Abbruzzese JL;
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正文语种 eng
中图分类肿瘤学;
关键词
Malignant neoplasm of gastrointestinal tract; Hedgehogs; Malignant Neoplasms; 刺猬; 角色;

机译：Malignant neoplasm of gastrointestinal tract;Hedgehogs;Malignant Neoplasms;刺猬;角色;

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1. Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. [J] . Xie K, Abbruzzese JL Cancer Cell . 2003,第4期

机译：发育生物学告知癌症：刺猬信号通路在上消化道癌症中的新兴作用。
2. KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers. [J] . Velho S, Corso G, Oliveira C, Advances in cancer research. . 2010,第Null期

机译：微卫星不稳定胃肠道癌症中的KRAS信号通路改变。
3. Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling Gastrointestinal defects of the Gas1 mutant involve dysregulated Hedgehog and Ret signaling [J] . Chen-Ming Fan, Shiying Jin, Sandrine Biau Biology Open . 2013,第2期

机译：Gas1突变体的胃肠道缺陷涉及刺猬和Ret信号失调Gas1突变体的胃肠道缺陷涉及刺猬和Ret信号失调Gas1突变体的胃肠道缺陷涉及刺猬和Ret信号失调
4. ACTIVATION OF SONIC HEDGEHOG PATHWAY IN UPPER-GASTROINTESTINAL TRACT SQUAMOUS CELL CANCER [C] . Xiaoli Ma, Haiji Sun, Yunshan Wang, 第四届国际后基因组生命科学技术学术论坛 . 2006

机译：上消化道牵引性鳞状细胞癌中声波通路的激活
5. Dichloro (4, 4'-bis (4, 4, 4-trifluorobutyl)-2, 2'-bipyridine1 platinum, a novel cisplatin analog, exhibits enhanced anticancer activity in preclinical models of Upper Gastrointestinal Cancers. [D] . Bapat, Samhita G. 2016

机译：二氯（4，4'-双（4，4，4-三氟丁基）-2，2'-联吡啶1铂，一种新型的顺铂类似物，在上消化道癌的临床前模型中表现出增强的抗癌活性。
6. Developmental signalling pathways in renal fibrosis: the roles of Notch Wnt and Hedgehog [O] . Maria Edeling, Grace Ragi, Shizheng Huang, -1

机译：肾纤维化中的发育信号通路：NotchWnt和Hedgehog的作用
7. Developmental biology informs cancer The emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers [O] . Xie Keping, Abbruzzese James L 2003

机译：发育生物学通知癌症刺猬信号通路在上消化道癌症中的新兴作用
8. Role of the Sonic Hedgehog Pathway for Prostate Cancer Progression [R] . Xie, J. 2008

机译：sonic Hedgehog通路在前列腺癌进展中的作用

Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.

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