A multigenic program mediating breast cancer metastasis to bone.

Kang Y; Siegel PM; Shu W; Drobnjak M; Kakonen SM; Cordon Cardo C; Guise TA; Massague J

首页> 外文期刊>Cancer Cell >A multigenic program mediating breast cancer metastasis to bone.

【24h】

A multigenic program mediating breast cancer metastasis to bone.

机译：介导乳腺癌转移至骨骼的多基因程序。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We investigated the molecular basis for osteolytic bone metastasis by selecting human breast cancer cell line subpopulations with elevated metastatic activity and functionally validating genes that are overexpressed in these cells. These genes act cooperatively to cause osteolytic metastasis, and most of them encode secreted and cell surface proteins. Two of these genes, interleukin-11 and CTGF, encode osteolytic and angiogenic factors whose expression is further increased by the prometastatic cytokine TGF beta. Overexpression of this bone metastasis gene set is superimposed on a poor-prognosis gene expression signature already present in the parental breast cancer population, suggesting that metastasis requires a set of functions beyond those underlying the emergence of the primary tumor.

机译：我们通过选择具有较高转移活性的人乳腺癌细胞系亚群并在这些细胞中过表达的功能验证基因来研究溶骨性骨转移的分子基础。这些基因协同作用导致溶骨性转移，并且大多数编码分泌的和细胞表面蛋白。这些基因中的两个，白介素11和CTGF，编码溶骨因子和血管生成因子，其表达因转移性细胞因子TGFβ而进一步增加。该骨转移基因集的过表达被叠加在父母乳腺癌人群中已经存在的预后不良的基因表达标记上，这表明转移所需要的功能超出了原发性肿瘤的潜在功能。

著录项

来源
《Cancer Cell》 |2003年第6期|共13页
作者
Kang Y; Siegel PM; Shu W; Drobnjak M; Kakonen SM; Cordon Cardo C; Guise TA; Massague J;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Neoplasm Metastasis; Skeletal bone; Malignant neoplasm of breast; osteolytic; 肿瘤转移;

机译：肿瘤转移;骨骼骨骼;乳腺恶性肿瘤;溶骨;肿瘤转移;

相似文献

外文文献
中文文献
专利

1. FuGENE6介导雌激素受体质粒HEGO5转染不同乳腺癌细胞株后受体的表达 [J] . 陶德定, 江敏, 冯永东, 癌症（英文版） . 2004,第010期
2. A multigenic program mediating breast cancer metastasis to bone. [J] . Kang Y, Siegel PM, Shu W, Cancer Cell . 2003,第6期

机译：介导乳腺癌转移至骨骼的多基因程序。
3. Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis [J] . Meixi Peng, Dan Yang, Yixuan Hou, Cell death & disease. . 2019,第3期

机译：通过PFKP和CS重新编程通过PFKP和CS重编程的细胞内柠檬酸盐积累增强了缺氧乳腺癌细胞侵袭和转移
4. The role of Type I interferons in immunoregulation of breast cancer metastasis to the bone. [J] . Slaney CY, M?ller A, Hertzog PJ, Oncoimmunology. . 2013,第1期

机译：I型干扰素在乳腺癌转移至骨骼的免疫调节中的作用。
5. Regulatory Networks of Integer Nonlinear Programming(RNINLP): a Model to Analyze Gene Regulatory Networks of Breast Cancer Metastasis [C] . Wanchun Luo, Lihong Gong, Kaichun Ren, World Congress on Intelligent Control and Automation;WCICA 2010 . 2010

机译：整数非线性规划（RNINLP）的调控网络：分析乳腺癌转移基因调控网络的模型。
6. The Role of the Obese Microenvironment in Mediating Breast Cancer Progression and Metastasis [D] . Ziemer, Lauren E. 2020

机译：肥胖微环境在介导乳腺癌进展和转移中的作用
7. Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis [O] . Meixi Peng, Dan Yang, Yixuan Hou, 2019

机译：通过PFKP和CS通过氧化的ATM介导的代谢重编程胞内柠檬酸盐的积累增强了缺氧性乳腺癌细胞的侵袭和转移
8. A multigenic program mediating breast cancer metastasis to bone [O] . Kang Yibin, Siegel Peter M., Shu Weiping, 2003

机译：介导乳腺癌转移至骨骼的多基因程序
9. Role of Megakaryocytes in Breast Cancer Metastasis to Bone. [R] . Mastro, A. M. 2014

机译：巨核细胞在乳腺癌骨转移中的作用。

A multigenic program mediating breast cancer metastasis to bone.

摘要

著录项

相似文献

相关主题

期刊订阅