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首页> 外文期刊>Microbial Pathogenesis >Characterization of methicillin resistant Staphylococcus aureus strains among inpatients and outpatients in a referral hospital in Tehran, Iran
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Characterization of methicillin resistant Staphylococcus aureus strains among inpatients and outpatients in a referral hospital in Tehran, Iran

机译：伊朗德黑兰转诊医院的住院病人和门诊病人中耐甲氧西林金黄色葡萄球菌菌株的特征

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Methicillin resistant Staphylococcus aureus is one of the most common causes of a variety of infections ranging from wound infections to urinary tract infections (UTI) in hospital and community. In this study during 3 years we characterized the antibiotic resistance patterns of 491 hospital acquired MRSA and community associated MRSA strains by the guidelines of clinical and laboratory standard institute. A combination of high resolution PhP typing method and SCCmec typing were used for clonal dissemination of isolates. Among all 491 MRSA strains, diverse PhP types consisting of 29 common types (CTs) and 4 single types (STs) and also 2 different SCCmec types (III and IVa) were detected. In addition, 18 CTs were common among CA- and HA-MRSA strains and the presence of all 4 STs was limited to HA-MRSA strains. All isolates were resistant to penicillin and high level resistance was observed against ciprofloxacin, erythromycin, tobramycin and kanamycin and the rate of resistance to most of the antibiotic tested among HA-MRSA was significantly higher than CA-MRSA isolates. Moreover, all isolates showed susceptibility to linezolid, vancomycin and quinupristin-dalfopristin and very low resistance to fusidic acid, nitrofurantoin and chloramphenicol were detected. Our findings illustrated the increasing rate of clonal dissemination and persistence of highly antibiotic resistant CA-MRSA strains in Tehran hospitals, and also indicated the important role of the hospitals as the reservoir of MRSA strains. (C) 2016 Elsevier Ltd. All rights reserved.
机译：耐甲氧西林的金黄色葡萄球菌是医院和社区中从伤口感染到尿路感染（UTI）的各种感染的最常见原因之一。在三年的研究中，我们根据临床和实验室标准协会的指南，对491家医院获得的MRSA和社区相关MRSA菌株的抗生素耐药性模式进行了表征。高分辨率PhP分型方法和SCCmec分型相结合，用于克隆的克隆传播。在所有491个MRSA菌株中，检测到多种PhP类型，包括29种常见类型（CT）和4种单一类型（ST），以及2种不同的SCCmec类型（III和IVa）。此外，在CA和HA-MRSA菌株之间共有18个CT，而所有4个ST的存在仅限于HA-MRSA菌株。所有分离株均对青霉素具有抗性，并观察到对环丙沙星，红霉素，妥布霉素和卡那霉素的高水平耐药性，并且在HA-MRSA中对大多数抗生素的耐药率均显着高于CA-MRSA分离株。此外，所有分离株均显示出对利奈唑胺，万古霉素和奎奴普丁-达福普汀的敏感性，并检测到对夫西地酸，呋喃妥因和氯霉素的抗性很低。我们的发现表明，在德黑兰医院中，高度耐药的CA-MRSA菌株的克隆传播率和持久性不断提高，也表明了医院作为MRSA菌株库的重要作用。 （C）2016 Elsevier Ltd.保留所有权利。

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