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首页> 外文期刊>Microsurgery. >Autologus groin lymph node transfer for 'sentinel lymph network' reconstruction after head-and-neck cancer resection and neck lymph node dissection: A case report
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Autologus groin lymph node transfer for 'sentinel lymph network' reconstruction after head-and-neck cancer resection and neck lymph node dissection: A case report

机译：自体腹股沟淋巴结转移用于头颈癌切除和颈淋巴结清扫术后的“前哨淋巴网”重建：一例报告

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Local or distant metastatic recurrence after therapy is observed in 20-30% of cases of head-and-neck cancer. An unfavorable course may occur after cervical lymph node dissection due to loss of immunoprotective lymph nodes in the head-and-neck region. To overcome this problem, we performed autologous lymph node transplantation from the groin after head-and-neck cancer resection and cervical lymph node dissection. The patient was a 63-year-old man with squamous cell carcinoma in the mesopharyngeal lateral wall. After tumor resection and right cervical lymph node dissection, a lymph node-containing superficial circumflex iliac artery perforator flap was transplanted from the left groin. Pathological examination showed that cancer had invaded the primary tumor tissue stump. Thus, radiotherapy (66 Gy) was performed for the residual tumor from days 28 to 84 after surgery. At 12 months after surgery, no recurrent lesion or has developed. The biopsy of flap and lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1) immunostaining shows creditable lymph network in the flap, compared with normal free flap. This case suggests that autologous lymph node transplantation may keep watch on cancer recurrence by reconstruction of the lymph node system in the resected region, and we suggest that this approach may be very useful in cancer therapy.
机译：在20-30％的头颈癌病例中观察到治疗后的局部或远处转移复发。颈淋巴结清扫后可能会发生不利的病程，原因是头颈部区域的免疫保护性淋巴结丢失。为了克服这个问题，我们在头颈癌切除术和颈淋巴结清扫术后从腹股沟处进行了自体淋巴结移植。该患者是一名63岁的男子，在咽喉侧壁患有鳞状细胞癌。肿瘤切除和右颈淋巴结清扫术后，从左腹股沟移植包含淋巴结的浅表super回动脉穿支皮瓣。病理检查表明，癌症已侵入原发肿瘤组织残端。因此，从术后28天到84天对残留的肿瘤进行放疗（66 Gy）。手术后12个月，未见复发病变或发展。与正常的游离皮瓣相比，皮瓣和淋巴管内皮透明质酸受体1（LYVE1）免疫染色的活检显示皮瓣中的淋巴网络可信。这种情况表明，自体淋巴结移植可以通过切除区域的淋巴结系统的重建来监视癌症的复发，我们建议这种方法在癌症治疗中可能非常有用。

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