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首页> 外文期刊>Microvascular Research: An International Journal >Wall shear stress differentially affects NO level in arterioles for volume expanders and Hb-based O2 carriers.
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Wall shear stress differentially affects NO level in arterioles for volume expanders and Hb-based O2 carriers.

机译：壁切应力对体积膨胀剂和基于Hb的O2载体的小动脉中的NO水平有不同的影响。

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摘要

The endothelium-derived nitric oxide (NO) is one of the mediators of smooth muscle (SM) relaxation. The release of NO by endothelium depends on the wall shear stress (WSS) to which endothelium is exposed. During hemodilution or isovolemic exchange transfusion with hemoglobin-based oxygen carriers (HBOCs) or volume expanders, the systemic hematocrit, blood viscosity, and blood flow rate are affected that would change WSS at endothelium. The effect of WSS-dependent NO release on SM NO availability has not been determined by direct measurements. We have formulated a mathematical model that is capable of predicting NO concentration in and around arteriolar vessels. The model predicts that the normal physiological SM NO concentration is approximately 100 nM at a physiological WSS of 24 dyn/cm(2) and the NO concentration is linearly dependent on WSS. With volume expanders, the SM NO concentration increases significantly and the levels of SM NO are significantly higher with increase in WSS. The SM NO decreases several-fold even for 5 microM luminal HBOC. For HBOCs, the NO levels are not restored to normal physiological level even with a significant increase in WSS (>48 dyn/cm(2)). These predictions are consistent with the results of animal studies of vascular tone following administration of HBOCs and volume expanders.
机译：内皮来源的一氧化氮（NO）是平滑肌（SM）松弛的介质之一。内皮细胞释放NO的过程取决于内皮细胞暴露的壁切应力（WSS）。在使用基于血红蛋白的氧气载体（HBOC）或体积膨胀剂进行血液稀释或等体积交换输血期间，会影响全身血细胞比容，血液粘度和血液流速，从而改变内皮细胞的WSS。 WSS依赖的NO释放对SM NO可用性的影响尚未通过直接测量确定。我们建立了一个数学模型，该模型能够预测小动脉血管及其周围的NO浓度。该模型预测正常生理SM NO浓度在24 dyn / cm（2）的生理WSS下约为100 nM，并且NO浓度线性依赖于WSS。使用体积膨胀器，随着WSS的增加，SM NO浓度显着增加，SM NO的水平显着更高。即使对于5 microM的腔HBOC，SM NO也会降低数倍。对于HBOC，即使WSS显着增加（> 48 dyn / cm（2）），NO水平也无法恢复到正常的生理水平。这些预测与施用HBOC和扩容剂后对动物血管张力的动物研究结果一致。

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