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首页> 外文期刊>Microvascular Research: An International Journal >Microcirculatory parameters measured in subcutaneous tissue of the mouse using a novel dorsal skinfold chamber.
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Microcirculatory parameters measured in subcutaneous tissue of the mouse using a novel dorsal skinfold chamber.

机译：使用新型背侧皮褶室在小鼠皮下组织中测量的微循环参数。

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摘要

The dorsal skinfold chamber (DSC) is a transparent devise useful for the long-term study of subcutaneous microcirculation. Commonly used chambers are made of metal, thus heavy and potentially stress including. Therefore, we developed a nonmetallic dorsal skinfold chamber and demonstrated that it performs as well as metal chambers. The essential structural parts of the nonmetallic chamber are made of polyacetal resin (Duracon), and its design was based on an existing titanium chamber. Both Duracon and titanium chambers were implanted onto an 8-week-old male BALB/c mice and microcirculatory parameters were compared. In subcutaneous venules, there were no significant differences between the chambers in terms of maximum blood velocity, blood flow rate, or the number of rolling or adhering leukocytes in vessels. In arterioles, main frequency of vasomotion showed no significant difference between the two types of chambers. This novel nonmetallic chamber frame was determined to be as practical as the metal frame. The nonmetallic chamber is about 40% lighter in weight than the metallic one, subjecting mice to less stress. Additionally, the chamber has greater applications in experimental use where metallic frames are unsuitable, such as those employing nonionizing radiation.
机译：背侧皮褶腔（DSC）是一种透明的设计，可用于长期研究皮下微循环。常用的腔室由金属制成，因此包括重物和潜在的应力。因此，我们开发了一种非金属背皮折叠腔，并证明了其性能与金属腔一样好。非金属腔室的主要结构部件由聚缩醛树脂（Duracon）制成，其设计基于现有的钛腔室。将Duracon和钛制腔室均植入8周大的雄性BALB / c小鼠中，并比较微循环参数。在皮下小静脉中，在最大血流速度，血液流速或血管中滚动或粘附白细胞的数量方面，各腔室之间无显着差异。在小动脉中，血管运动的主要频率在两种类型的腔室之间没有显示出显着差异。该新颖的非金属腔室框架被确定为与金属框架一样实用。非金属腔室的重量比金属腔室轻约40％，使小鼠承受的压力较小。另外，该腔室在不适合金属框架的实验用途中具有更大的应用，例如那些采用非电离辐射的框架。

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