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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Opening of K-ATP Channel Regulates Tonic Currents From Pyramidal Neurons in Rat Brain
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Opening of K-ATP Channel Regulates Tonic Currents From Pyramidal Neurons in Rat Brain

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Background: ATP-sensitive K+ (K-ATP) channels couple metabolic state to cellular excitability. Activation of neuronal and astrocytic mitochondrial K-ATP (mitoK(ATP)) channels regulates a variety of neuronal functions. However, less is known about the impact of mitoK(ATP) on tonic.-aminobutyric acid (GABA) inhibition. Tonic GABA inhibition is mediated by the binding of ambient GABA on extrasynaptic GABA A-type receptors (GABA(A)Rs) and is involved in regulating neuronal excitability. Methods: We determined the impact of activation of K-ATP channels with diazoxide (DIZ) on tonic inhibition and recorded tonic current from rat cortical layer 5 pyramidal cells by patch-clamp recordings. Results: We found that neonatal tonic current increased with an increase in GABA concentration, which was partially mediated by the GABA A-type receptor (GABA(A)R) alpha 5, and likely the delta subunits. Activation of K-ATP channels resulted in decreased tonic current in newborns, but there was increased tonic current during the second postnatal week. Conclusions: These findings suggest that activation of K-ATP channels with DIZ regulates GABAergic transmission in neocortical pyramidal cells during development.

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