Inhibition of Gap Junction Intercellular Communications in Cell Culture by Polycyclic Aromatic Hydrocarbons(PAH)in the Absence of PAH Metabolism

Ju.Ju.Sharovskaja; A.V.Vaiman; N.A.Solomatina; V.A.Kobliakov

首页> 外文期刊>Biochemistry >Inhibition of Gap Junction Intercellular Communications in Cell Culture by Polycyclic Aromatic Hydrocarbons(PAH)in the Absence of PAH Metabolism

【24h】

Inhibition of Gap Junction Intercellular Communications in Cell Culture by Polycyclic Aromatic Hydrocarbons(PAH)in the Absence of PAH Metabolism

机译：缺乏PAH代谢时多环芳烃（PAH）抑制细胞培养中的间隙连接细胞间通讯。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We have studied the effect of polycyclic aromatic hydrocarbons(PAH)on gap junction intercellular communications(GJIC)in culture of hepatoma cells Hep G2 and G27.Carcinogenic PAH inhibited GJIC in both cultures in contrast to non-carcinogenic PAH.We showed that both constitutive and inducible expressions of mRNAs of Ah receptor and cytochrome P4501A1(the main isoform involved in PAH metabolism)were absent in hepatoma G27 cells.We concluded that the initial,non-metabolized molecules of carcinogenic PAH are responsible for changes in GJIC through interaction with an unknown factor in the cellular membrane.

机译：我们研究了多环芳烃（PAH）对肝癌细胞Hep G2和G27的间隙连接细胞间通讯（GJIC）的影响。与非致癌PAH相比，致癌PAH在两种培养物中均抑制GJIC。肝癌G27细胞中缺少Ah受体和细胞色素P4501A1（参与PAH代谢的主要同工型）的mRNA的表达和诱导表达。细胞膜中未知的因子。

著录项

来源
《Biochemistry》 |2004年第4期|共7页
作者
Ju.Ju.Sharovskaja; A.V.Vaiman; N.A.Solomatina; V.A.Kobliakov;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
marine proteobacteria; marinomonas vaga; LPS; lipid A;

机译：海洋细菌;迷迭香;LPS;脂质A;

相似文献

外文文献
中文文献
专利

1. Inhibition of Gap Junction Intercellular Communications in Cell Culture by Polycyclic Aromatic Hydrocarbons(PAH)in the Absence of PAH Metabolism [J] . Ju.Ju.Sharovskaja, A.V.Vaiman, N.A.Solomatina, Biochemistry . 2004,第4期

机译：缺乏PAH代谢时多环芳烃（PAH）抑制细胞培养中的间隙连接细胞间通讯。
2. Interactive effects of inflammatory cytokine and abundant low-molecular-weight PAHs on inhibition of gap junctional intercellular communication, disruption of cell proliferation control, and the AhR-dependent transcription [J] . Kabatkova Marketa, Svobodova Jana, Pencikova Katerina, Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2015,第1期

机译：炎性细胞因子和丰富的低分子量PAHs对间隙连接细胞间通讯的抑制，细胞增殖控制的破坏和AhR依赖性转录的相互作用
3. Ah Receptor-Independent Inhibition of Gap Junction Intercellular Communications in Hepatoma 27 Cell Culture by Poly cyclic Aromatic Hydrocarbons [J] . N. A. BoIotina, Yu. Yu. Sharovskaya, V. A. Kobliakov Cell and Tissue Biology . 2009,第3期

机译：多环芳烃对肝癌细胞27细胞培养中间隙连接细胞间通讯的Ah受体独立抑制。
4. Polycyclic aromatic hydrocarbons (PAHs) have much received attention as one of thefundamental components of organic devices.1 Although PAHs are usually composed ofhexagons (benzenoid systems),embedding odd-membered rings such as pentagons orheptagons (non-benzenoid systems) into the molecular core is a promising methodology tomodify their electronic properties,such as aromaticity,redox ability and/or spin state [C] . Koki Horii, Akihito Konishi, MakotoYasuda 日本化学会春季年会 . 2020

机译：多环芳烃（PAHS）作为有机器件的金融组件之一，多环芳烃（PAHS）有很多人受到关注.1虽然PAHS通常由过爆（苯甲酸系统）组成，但嵌入奇数元环，例如Pentagons Orheptagons（非苯骨系统）进入分子核心是一个有希望的方法，可以清理它们的电子性质，例如芳香性，氧化还原能力和/或旋转状态
5. Polycyclic Aromatic Hydrocarbons and Oxygenated Polycyclic Aromatic Hydrocarbons (PAHs and Oxy-PAHs) in House Dust Samples in Relation to Smoking Behavior in the Home [D] . Azure, Lorren E. 2016

机译：多环芳烃和含氧多环芳烃（PAHS和OXY-PAHS）在房屋粉尘样品中，在家中的吸烟行为相关
6. Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C [O] . Brad L. Upham, Ludek Bláha, Pavel Babica, -1

机译：香烟烟雾中普遍存在的多环芳烃的促肿瘤特性如通过磷脂酰胆碱特异性磷脂酶C抑制间隙连接细胞间通讯所表明
7. Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C [O] . Brad L. Upham, Ludek Bláha, Pavel Babica, 2008

机译：通过磷脂酰胆碱特异性磷脂酶C抑制间隙连接细胞间连通的抑制表明，肿瘤促进卷烟血液普遍的多环芳烃烃

Inhibition of Gap Junction Intercellular Communications in Cell Culture by Polycyclic Aromatic Hydrocarbons(PAH)in the Absence of PAH Metabolism

摘要

著录项

相似文献

相关主题

期刊订阅