MYC has a key role in gastric carcinogenesis. We evaluated MYC copy number and protein expression in non-neoplasic, intestinal metaplasia, and gastric cancer samples from five young adults. We observed a significant increase of MYC amplification with the evolution of carcinogenesis process. MYC overexpression was observed in intestinal metaplasia and neoplastic tissue from all patients with intestinal-type gastric cancer and from no patients with diffuse type. MYC copy number and expression can be biomarkers of gastric malignance.
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