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首页> 外文期刊>Biochemistry >MULTIFUNCTIONAL ACTIVITY OF THE EXTRACELLULAR DOMAIN OF THE M-TYPE (180 KDA) MEMBRANE RECEPTOR FOR SECRETORY PHOSPHOLIPASES A(2)
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MULTIFUNCTIONAL ACTIVITY OF THE EXTRACELLULAR DOMAIN OF THE M-TYPE (180 KDA) MEMBRANE RECEPTOR FOR SECRETORY PHOSPHOLIPASES A(2)

机译：M型（180 KDA）膜磷脂受体胞外域对分泌型磷脂酶A（2）的多功能活性

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摘要

M-type (180 kDa) receptors for secretory phospholipases A(2) (sPLA(2)s) are thought to mediate some of the physiological effects of group I sPLA(2), including smooth muscle contraction and cell proliferation. The M-type sPLA(2) receptor is a large glycoprotein composed of several distinct extracellular domains which belongs to the C-type lectin superfamily. This receptor binds with high affinity both pancreatic group I and inflammatory group II sPLA(2)s as well as various sPLA(2)s purified from snake venoms. This paper shows that the rabbit M-type sPLA(2) receptor is a multifunctional protein which is able to promote cell adhesion on type I and IV collagens most probably via its N-terminal fibronectin-like type II domain. It also shows that binding of sPLA(2)s to a recombinant soluble form of this receptor is associated with a noncompetitive inhibition of phospholipase A(2) activity.
机译：分泌型磷脂酶A（2）（sPLA（2）s）的M型（180 kDa）受体被认为介导了I组sPLA（2）的某些生理效应，包括平滑肌收缩和细胞增殖。 M型sPLA（2）受体是一种大型糖蛋白，由几个不同的胞外域组成，属于C型凝集素超家族。该受体以高亲和力结合胰腺I组和炎症II组sPLA（2）以及从蛇毒中纯化的各种sPLA（2）。本文显示，兔M型sPLA（2）受体是一种多功能蛋白，最有可能通过其N端纤连蛋白样II型结构域促进细胞粘附在I型和IV型胶原上。它还显示sPLA（2）与该受体的重组可溶性形式的结合与磷脂酶A（2）活性的非竞争性抑制有关。

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