Pellino enhances innate immunity in Drosophila.

Haghayeghi A.; Sarac A.; Czerniecki S.; Grosshans J.; Schock F.

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Pellino enhances innate immunity in Drosophila.

机译：Pellino增强果蝇的先天免疫力。

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The innate immune response is a defense mechanism against infectious agents in both vertebrates and invertebrates, and is in part mediated by the Toll pathway. Toll receptor activation upon exposure to bacteria causes stimulation of Pelle/IRAK kinase, eventually resulting in translocation of the transcription factor NF- kappa B to the nucleus. Here we show that Pellino, a highly conserved protein interacting with activated Pelle/IRAK, acts as a positive regulator of innate immunity in Drosophila.

机译：先天性免疫应答是脊椎动物和无脊椎动物中针对传染原的防御机制，部分由Toll途径介导。暴露于细菌后的Toll受体激活会刺激Pelle / IRAK激酶，最终导致转录因子NF-κB易位至细胞核。在这里，我们证明了Pellino是一种高度保守的蛋白质，与活化的Pelle / IRAK相互作用，在果蝇中起着先天免疫的正向调节作用。

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来源
《Mechanisms of Development》 |2010年第6期|共7页
作者
Haghayeghi A.; Sarac A.; Czerniecki S.; Grosshans J.; Schock F.;
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正文语种 eng
中图分类普通生物学;
关键词
biochemical pathways; biochemical receptors; biochemical transport; defence mechanisms; enzyme activity; enzymes; immune response; immunity; kinases; transcription factors; Drosophila;

机译：生化途径;生化受体;生化转运;防御机制;酶活性;酶;免疫应答;免疫;激酶;转录因子;果蝇;

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1. Pellino enhances innate immunity in Drosophila. [J] . Haghayeghi A., Sarac A., Czerniecki S., Mechanisms of Development . 2010,第5a6期

机译：Pellino增强果蝇的先天免疫力。
2. INVESTIGATING THE E3 UBIQUITIN LIGASE PELLINO2 FUNCTIONS IN INNATE AND ADAPTIVE IMMUNE RESPONSES [J] . Oleszycka E., Humphries F., Wang B., Cytokine . 2016,第Null期

机译：研究E3泛素连接酶PELLINO2在先天和适应性免疫应答中的作用
3. Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila [J] . Shanming Ji, Ming Sun, Xiudeng Zheng, Nature Communications . 2014,第1期

机译：Pellino的细胞表面定位可通过控制果蝇中的MyD88更新来拮抗Toll介导的先天免疫信号转导。
4. A Temporal Analysis of the Bovine Innate Immune ResponseA Temporal Analysis of the Bovine Innate Immune Response: The Identification and Characterization of Host Defense Peptides by Mass Spectrometry [C] . Jeffrey A. DeGrasse, Jamie L. Boehmer, Kevin J. Shefcheck, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：牛先天免疫应答牛先天性免疫应答的时间分析：质谱法鉴定和表征宿主防毒肽
5. Effect of Innate Immune Collectin Surfactant Protein D and Adaptive Immune Protein IgM on Enhancing the Clearance of Late Apoptotic Cells by Alveolar Macrophages [D] . Litvack, Michael L. 2011

机译：先天性免疫收集蛋白表面活性蛋白D和适应性免疫蛋白IgM对增强肺泡巨噬细胞清除晚期凋亡细胞的作用
6. Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila [O] . Shanming Ji, Ming Sun, Xiudeng Zheng, -1

机译：Pellino的细胞表面定位可通过控制果蝇中的MyD88更新来拮抗Toll介导的先天免疫信号转导。
7. Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system [O] . Goh Eddy T. H., Arthur J. Simon C., Cheung Peter C. F., 2012

机译：鉴定先天免疫系统中激活E3泛素连接酶Pellino 1的蛋白激酶

Pellino enhances innate immunity in Drosophila.

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