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首页> 外文期刊>Balkan journal of medical genetics: BJMG >INTERLEUKIN-18 PROMOTER GENE POLYMORPHISMS ARE NOT ASSOCIATED WITH MYOCARDIAL INFARCTION IN TYPE 2 DIABETES IN SLOVENIA
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INTERLEUKIN-18 PROMOTER GENE POLYMORPHISMS ARE NOT ASSOCIATED WITH MYOCARDIAL INFARCTION IN TYPE 2 DIABETES IN SLOVENIA

机译：斯洛文尼亚2型糖尿病的白细胞介素18启动子基因多态性与心肌梗死无关

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摘要

Type 2 diabetes is a major risk factor for myocardial infarction (MI) and chronic inflammation may play a central role in both diseases. Interleukin (IL)-18 is a potent proinflammatory cytokine, which is considered important in acute coronary syndromes and type 2 diabetes. We investigated the association of the -137 (G>C), polymorphism (rsl87238) and the-607 (OA) polymorphism (rs1946518) of the IL-18 gene promoter region in 495 Caucasians with type 2 diabetes, of whom 169 had MI and 326 subjects had no clinically evident coronary artery disease (controls). We also investigated the impact of these polymorphisms on the serum IL-18 level in subsets of both groups and in a normal group. Genotype distributions of the polymorphisms showed no significant difference between cases and controls. However, IL-18 serum levels were significantly lower in diabetics with the 137 CC genotype than in those with other genotypes (241.5 +- 132.7 ng/L vs. 340.2 +- 167.4 ng/L; p <0.05). High sensitivity C-reactive protein and IL-18 serum levels were higher in diabetics in the MI group than in the control group. We conclude that these IL-18 promoter gene polymorphisms are not risk factors for MI in Caucasians with type 2 diabetes.
机译：2型糖尿病是心肌梗塞（MI）的主要危险因素，慢性炎症可能在两种疾病中都起着核心作用。白介素（IL）-18是一种有效的促炎细胞因子，在急性冠脉综合征和2型糖尿病中被认为很重要。我们调查了495位2型糖尿病高加索人IL-18基因启动子区域的-137（G> C）多态性（rsl87238）和-607（OA）多态性（rs1946518）的相关性326名受试者没有临床上明显的冠状动脉疾病（对照）。我们还研究了这些多态性对两组亚组和正常组中血清IL-18水平的影响。多态性的基因型分布显示病例与对照之间无显着差异。但是，具有137 CC基因型的糖尿病患者的IL-18血清水平显着低于其他基因型的糖尿病患者（241.5±132.7 ng / L与340.2±167.4 ng / L; p <0.05）。 MI组糖尿病患者的高敏C反应蛋白和IL-18血清水平高于对照组。我们得出结论，这些IL-18启动子基因多态性不是2型糖尿病高加索人MI的危险因素。

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