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首页> 外文期刊>Balkan journal of medical genetics: BJMG >CYTOGENETIC AND MORPHOLOGICAL ANALYSIS OF DE NOVO ACUTE MYELOID LEUKEMIA IN ADULTS: A SINGLE CENTER STUDY IN JORDAN
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CYTOGENETIC AND MORPHOLOGICAL ANALYSIS OF DE NOVO ACUTE MYELOID LEUKEMIA IN ADULTS: A SINGLE CENTER STUDY IN JORDAN

机译：成人急性重症髓性白血病的细胞遗传学和形态学分析：在约旦的单中心研究

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摘要

Acute myeloid leukemia (AML) in adults is known to be a heterogeneous disease with diverse chromosomal abnormalities. Some of these abnormalities are found with a high incidence in specific ethnic groups and in certain geographical areas. We report the results of cytogenetic studies of 35 adult Jordanian Arab patients with de novo AML diagnosed according to the French-American-British (FAB) criteria. Four patients did not have meta-phases secondary to hypocellular bone marrow. The most common morphological subtype was M5 (55%) followed by M3 (19%). Cytogenetic abnormalities were present in 20 patients (65%); t(15;17) translocation in six patients (19%), inv(16) in four patients (13%), t(ll;17) in two patients (4%), and the t(8;21) translocation was not present in any patient. Trisomy 8 was the most common numerical chromosomal abnormality [four patients (13%)]. There were variations and similarities with similar ethninc Arab populations. The most common chromosomal abnormalities were t(15;17), +8 and inv(16). Further and larger crossborder studies are needed.
机译：成人急性髓细胞白血病（AML）是一种具有多种染色体异常的异质性疾病。在某些种族和某些地理区域中发现了其中一些异常高发的疾病。我们报告了根据法国-美国-英国（FAB）标准诊断的35例约旦阿拉伯成人患者从头AML的细胞遗传学研究结果。四名患者没有继发于细胞低位骨髓的中期。最常见的形态亚型是M5（55％），其次是M3（19％）。细胞遗传异常出现在20例患者中（65％）;六名患者（19％）的t（15; 17）易位，四名患者（13％）的inv（16），两名患者（4％）的t（ll; 17）和t（8; 21）易位没有患者。 8号染色体是最常见的数字染色体异常[4例（13％）]。与相似的阿拉伯民族人口存在差异和相似性。最常见的染色体异常是t（15; 17），+ 8和inv（16）。需要更多和更大的跨界研究。

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