...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology >A comparison of two invasive techniques in the management of intractable pain due to inoperable pancreatic cancer: neurolytic celiac plexus block and videothoracoscopic splanchnicectomy.
【24h】

A comparison of two invasive techniques in the management of intractable pain due to inoperable pancreatic cancer: neurolytic celiac plexus block and videothoracoscopic splanchnicectomy.

机译：治疗无法手术的胰腺癌所引起的顽固性疼痛的两种侵入性技术的比较：神经溶解性腹腔神经丛阻滞和电视胸腔镜内脏切除术。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND AIMS: Pancreatic cancer is characterized by a constant deterioration in quality of life, excruciating pain and progressive cachexia. The aim of this study was to compare the effectiveness of two invasive methods of pain treatment in these patients: neurolytic coeliac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) to a conservatively treated control group concerning pain, quality of life and opiates' consumption. PATIENTS AND METHODS: Fifty nine patients suffering from pain due to inoperable pancreatic cancer were treated invasively with NCPB (N=35) or VSPL (N=24) in two non-randomised, prospective, case-controlled protocols. Intensity of pain (VAS-pain), quality of life (FACIT and QLQ C30) and opioid intake were compared between the groups and to a control group of patients treated conservatively before the procedure and after 2 and 8 weeks of follow-up. The analysis was performed retrospectively using meta-analysis statistics. RESULTS: Both methods of invasive pain treatment resulted in significant reduction of pain (VSPL effect size=11.27, NCPB effect size=7.29) and fatigue (effect sizes, respectively, 1.23 and 3.37). NCPB improved also significantly physical, emotional and social well-being (effect sizes, respectively, 2.37, 4.13 and 7.51) which was not observed after VSPL. No influence on ailments characteristic for the disease was demonstrated. Mean daily opioid consumption was significantly decreased after both procedures. There was no perioperative mortality and no major morbidity. CONCLUSION: Both NCPB and VSPL provide significant reduction of pain and improvement of quality of life in inoperable pancreatic cancer patients. They present rather similar efficacy, but lower invasiveness of NCPB, in combination with its more positive effect on quality of life, pre-disposes it as being the preferred method.
机译：背景与目的：胰腺癌的特点是生活质量不断下降，疼痛加剧和恶病质不断发展。本研究的目的是比较两种治疗疼痛的侵入性方法在这些患者中的有效性：神经溶解性腹腔神经丛阻滞（NCPB）和电视胸腔镜内脏切除术（VSPL）与保守治疗的对照组在疼痛，生活质量和鸦片消费方面的有效性。患者和方法：对59例因无法手术的胰腺癌而痛苦的患者，采用NCPB（N = 35）或VSPL（N = 24）进行了两种非随机，前瞻性，病例对照的侵入性治疗。比较两组之间的疼痛强度（VAS疼痛），生活质量（FACIT和QLQ C30）和阿片类药物的摄入量，并与手术前以及术后2周和8周后接受保守治疗的对照组患者进行比较。使用荟萃分析统计数据进行回顾性分析。结果：这两种侵入性疼痛治疗方法均显着减轻了疼痛（VSPL效应量= 11.27，NCPB效应量= 7.29）和疲劳（效应量分别为1.23和3.37）。 NCPB也显着改善了身体，情感和社交的幸福感（效果大小分别为2.37、4.13和7.51），这在VSPL之后并未观察到。没有显示出对疾病特征疾病的影响。两次手术后，平均每日阿片类药物消耗量均显着降低。没有围手术期死亡率，也没有大的发病率。结论：NCPB和VSPL均可显着减轻无法手术的胰腺癌患者的疼痛并改善生活质量。他们表现出相当相似的功效，但是NCPB的侵袭性较低，加上对生活质量的更积极的影响，使其成为首选方法。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号