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首页> 外文期刊>European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology >A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies.
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A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies.

机译：局部晚期胃肠道恶性肿瘤放疗方式与连续5-FU输注相结合的研究。

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摘要

Aim. We describe the feasibility of combining infusional 5-fluorouracil (5-FU) with intraoperative radiation therapy (IORT). Methods. Patients with surgically resectable locally advanced gastrointestinal cancers were treated concurrently during surgery with IORT and a 72 h infusion of 5-FU. Patients without previous external beam radiation therapy (EBRT) were subsequently treated with EBRT (40-50Gy) concurrent with a 21-day continuous infusion of 5-FU. Pancreatic, gastric, duodenal, ampullary, recurrent colorectal, and recurrent anal cancer were included. Results. During IORT/5-FU, no chemotherapy-related grade III or IV hematologic or gastrointestinal toxicity was noted. Post-surgical recovery or wound healing was not affected. One of nine patients who received post-operative radiation required a treatment break. During follow-up, there were more complications in patients with pelvic tumours, especially those with previous radiation. Nine patients have had local and/or local regional recurrences, two of these in the IORT field. Conclusions. Treatment with a combination of IORT and 5-FU followed by EBRT and 5-FU is feasible. However, long-term complications may be increased in previously irradiated recurrent pelvic tumours.
机译：目标。我们描述了将5-氟尿嘧啶（5-FU）与术中放疗（IORT）相结合的可行性。方法。手术切除的局部晚期胃肠道癌患者在手术期间同时接受IORT和72小时的5-FU输注治疗。先前未接受外部束放射治疗（EBRT）的患者随后接受EBRT（40-50Gy）治疗，并连续21天连续输注5-FU。包括胰腺癌，胃癌，十二指肠癌，壶腹癌，复发性结直肠癌和复发性肛门癌。结果。在IORT / 5-FU期间，未发现与化疗有关的III或IV级血液学或胃肠道毒性。术后恢复或伤口愈合不受影响。接受术后放射治疗的九名患者中有一名需要中断治疗。在随访期间，盆腔肿瘤患者，尤其是先前接受过放疗的患者，并发症更多。 9名患者发生了局部和/或局部区域复发，其中两个在IORT领域中。结论。将IORT和5-FU联合使用EBRT和5-FU进行联合治疗是可行的。但是，以前接受过治疗的复发性盆腔肿瘤可能会增加长期并发症。

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