Anti-cancer potential of Tetracarpidium conophorum (African walnut) seed oil on prostate carcinogenesis

Esosa Uhunmwangho; Celestina Olafusi; Ifeoluwatomi Akinyemi

首页> 外文期刊>Scientific Research and Essays >Anti-cancer potential of Tetracarpidium conophorum (African walnut) seed oil on prostate carcinogenesis

【24h】

Anti-cancer potential of Tetracarpidium conophorum (African walnut) seed oil on prostate carcinogenesis

机译：

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Prostate cancer is the leading cause of mortality in men worldwide, and dietary fat influence its incidence. This study investigated the effect of feeding Tetracarpidium conophorum seed oil (TCSO) on 3-methylcholanthrene (MCA) induced prostate cancer in Wistar rats, the expression of cyclooxygenase-2 (COX-2) and peroxisome proliferator activated receptor gamma (PPAR-?) in the prostatic tissues. The TCSO was extracted with n-hexane in a Soxhlet apparatus and characterized by gas chromatography. Forty-eight male wistar rats (4 weeks old) were divided into three groups of 16 rats each and fed for 12 weeks. Group A and B animals were fed with diet containing TCSO extract. The animals in Groups A and C received intraperitoneally a dose of MCA (150 mg/kg) after 30 days of feeding. Groups A and B rats were fed with diet containing 10 of extracted TCSO throughout the period of the experiment. Results showed that COX-2 activity significantly decreased (p 0.05) in Group A (0.71±0.07) and B (0.60±0.05) when compared with Group C (1.17±0.10) with increased COX-2 expression. PPAR-gamma activity was significantly increased (p 0.05) in Group A (1.89±0.13) and B (2.30±0.15) in comparison with Group C (1.16±0.10) which has the lowest PPAR-gamma expression. TCSO extract delayed latency period in Group A where lumps were observed after 4 weeks of 3-methylcholanthrene induction in comparison with Group C where lumps were observed in less than 2 weeks of MCA induction. Gamma-linoleic acid, docosahexaenoic acid and myristoleic acid were higher in the liver cell membrane of animals in Group A compared to animals in Group C. This work therefore showed that TCSO contains bioactive components that may oppose prostate carcinogenesis induced by MCA.

著录项

来源
《Scientific Research and Essays》 |2022年第1期|1-7|共7页
作者
Esosa Uhunmwangho; Celestina Olafusi; Ifeoluwatomi Akinyemi;
展开▼
作者单位

Bioactive Lipids in Cancer and Toxicology Research Laboratory, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Medical Sciences;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Cyclooxygenase-2; linoleic acid; prostate cancer; Tetracarpidium conophorum; polyunsaturated fatty acid;

相似文献

外文文献
中文文献

1. Chick bioassay of available methionine and sulphur amino acids (SAA). Assay of African oil bean meal (Pentaclethra macrophyllabenth), conophor seed meal (Tetracarpidium conophorum, hutch) and groundnut meals (Arachis hypogeaelinn) [J] . Michael C. Njike, Akpan U. Mba, Victor A. Oyenuga journal of the science of food and agriculture . 1975,第6期

机译：Chick bioassay of available methionine and sulphur amino acids (SAA). Assay of African oil bean meal (Pentaclethra macrophyllabenth), conophor seed meal (Tetracarpidium conophorum, hutch) and groundnut meals (Arachis hypogeaelinn)
2. Protein Extraction from Conophor (Tetracarpidium conophorum) Seed [J] . T. E. EKPENYONG journal of food science . 1986,第2期

机译：Protein Extraction from Conophor (Tetracarpidium conophorum) Seed
3. Chemical composition of oil from Tetracarpidium conophorum ((Mull. Arg.)Hutch. and Dalz.) nuts [J] . Tchiegang C, Kapseu C, Parmentier M Journal of Food Lipids . 2001,第2期

机译：Chemical composition of oil from Tetracarpidium conophorum ((Mull. Arg.)Hutch. and Dalz.) nuts

Anti-cancer potential of Tetracarpidium conophorum (African walnut) seed oil on prostate carcinogenesis

摘要

著录项

相似文献

相关主题

期刊订阅