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首页> 外文期刊>Balkan journal of medical genetics: BJMG >LACK OF ASSOCIATION BETWEEN VARIANTS WITHIN THE AHSG, HCRT AND NPY2R GENES AND ANTHROPOMETRICAL PARAMETERS IN CZECH POST-MONICA STUDY
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LACK OF ASSOCIATION BETWEEN VARIANTS WITHIN THE AHSG, HCRT AND NPY2R GENES AND ANTHROPOMETRICAL PARAMETERS IN CZECH POST-MONICA STUDY

机译：在捷克-莫尼卡研究中，AHSG，HCRT和NPY2R基因内的变体之间缺乏关联以及对射光参数

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The aim of this study was to examine single nu-cleotide polymorphisms (SNPs) of candidate genes alpha2-Heremans-Schmid glycoprotein (AHSG, rs4917), Hypocretin {HCRT, rs760282) and Neuropetide Y2 receptor (NPY2R, rs 1047214), which are known to have a potential effect on body mass index (BMI) and other indicators of obesity. A population study was performed in 2007/2008 on 2559 adults (1191 males and 1368 females) from the Czech post-MONICA project. The SNPs were examined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We did not find any significant association between the examined SNPs and BMI across the whole population. A significantly lower triglyceride level was found in the AHSG gene CC homozygotes compared to T allele carriers in the entire population (p = 0.009). In conclusion, we are not able to confirm the hypothesis that polymorphisms within the AHSG, HCRT and NPY2R genes are major genetic determinants of BMI and plasma lipids in the Czech-Slavonic population.
机译：这项研究的目的是检查候选基因alpha2-Heremans-Schmid糖蛋白（AHSG，rs4917），Hypocretin（HCRT，rs760282）和Neuropetide Y2受体（NPY2R，rs 1047214）的单核苷酸多态性（SNP）。已知对体重指数（BMI）和其他肥胖指标有潜在影响。 2007/2008年对捷克后摩尼卡项目的2559名成年人（1191名男性和1368名女性）进行了人口研究。使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检查SNP。在整个人群中，我们未发现所检查的SNP与BMI之间有任何显着关联。在整个人群中，AHSG基因CC纯合子中的甘油三酸酯水平明显低于T等位基因携带者（p = 0.009）。总之，我们无法证实AHSG，HCRT和NPY2R基因内的多态性是捷克斯拉夫族人群BMI和血浆脂质的主要遗传决定因素。

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