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首页> 外文期刊>International journal of urology: official journal of the Japanese Urological Association >Effects of platelet-activating factor on nitrergic transmission in rabbit corpus cavernosum.
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Effects of platelet-activating factor on nitrergic transmission in rabbit corpus cavernosum.

机译：血小板活化因子对兔海绵体硝态氮传递的影响。

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AIM: The information currently available suggests that nonadrenergic noncholinergic (NANC) transmitters, particularly nitric oxide, are involved in the relaxation of penile erectile tissues. Platelet-activating factor (PAF) is a chemical mediator and is involved in many physiological and pathophysiological events. It is well known that several of the vascular actions of PAF are mediated by the generation of nitric oxide. We designed this study to test the hypothesis that PAF has an effect on NANC responses in rabbit corpus cavernosum strips. METHODS: Rabbit corpus cavernosum strips were precontracted with phenylephrine (10(-5) mol/L). Isometric tension changes produced by carbachol (10(-9)-10(-5) mol/L), sodium nitroprusside (10(-8)-10(-5) mol/L) and electrical field stimulation (for 10 s at sequential frequencies of 2, 4, 8, 16, and 32 Hz as square-wave pulses of 50 mV) were recorded with a pressure transducer. These relaxations were compared to those obtained in the presence of PAF. RESULTS: PAF had no effect on endothelium-dependent, endothelium-independent or electrical field stimulation-induced NANC relaxation responses in isolated rabbit corpus cavernosum strips. There was no statistically significant difference between the pD(2) and E(max) values for carbachol or sodium nitroprusside in the presence of PAF. CONCLUSIONS: Our results suggest that PAF does not modify the endothelium-dependent, endothelium-independent or electrical field stimulation-induced NANC relaxation responses in isolated rabbit corpus cavernosum strips.
机译：目的：目前可获得的信息表明，非肾上腺能非胆碱能（NANC）递质，特别是一氧化氮，参与了阴茎勃起组织的松弛。血小板活化因子（PAF）是一种化学介质，参与许多生理和病理生理事件。众所周知，PAF的几种血管作用是由一氧化氮的产生介导的。我们设计了这项研究，以检验PAF对兔海绵体条中NANC反应有影响的假设。方法：将兔海绵体条与去氧肾上腺素（10（-5）mol / L）预包合。卡巴胆碱（10（-9）-10（-5）mol / L），硝普钠（10（-8）-10（-5）mol / L）和电场刺激（在10 s下产生10 s产生的等轴测张力变化）用压力传感器记录2、4、8、16和32 Hz的连续频率（50 mV的方波脉冲）。将这些弛豫与在PAF存在下获得的弛豫进行比较。结果：PAF对离体兔海绵体条中内皮依赖性，内皮依赖性或电场刺激引起的NANC松弛反应无影响。在存在PAF的情况下，卡巴胆碱或硝普钠的pD（2）和E（max）值之间无统计学显着差异。结论：我们的结果表明，PAF不会改变离体兔海绵体条中内皮依赖性，内皮依赖性或电场刺激引起的NANC松弛反应。

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