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首页> 外文期刊>Medecine et maladies infectieuses >Is there an excess of AIDS-related mortality in Aquitaine? Data collected through the French mandatory reporting system, 1982-2005
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Is there an excess of AIDS-related mortality in Aquitaine? Data collected through the French mandatory reporting system, 1982-2005

机译：阿基坦的艾滋病相关死亡率是否过高？通过法国强制性报告系统收集的数据，1982-2005年

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OBJECTIVES: The mortality rate among AIDS patients reported through the French mandatory reporting system since 1982 is particularly high in Aquitaine, a south west area of France. This study was made to confirm that mortality was higher in Aquitaine patients than in the rest of France, and to determine its causes. DESIGN: All the cases reported between January 1982 and June 2005 were included. Cox's proportional hazard models were used to determine the relative risk (RR) of death among patients living in Aquitaine. Two periods were considered to take into account the introduction of highly active antiretroviral therapy (HAART) in 1996. RESULTS: Since 1982, 60,212 AIDS patients were reported. After adjustment on the main patient features, the risk of death was significantly higher in AIDS patients living in Aquitaine than in other regions (RR=1.12; IC95%=[1.06-1.18]) before the introduction of HAART. After 1996, this difference did not persist, and an opposite trend was even observed (RR=0.90; IC95%=[0.75-1.09]). CONCLUSIONS: The higher overall mortality rate in Aquitaine was due to a higher risk of death in that area before 1996. Several hypotheses can explain this result, such as a less exhaustive notification, or different characteristics of the subjects. The opposite trend that was observed after the introduction of HAART will have to be checked in the next few years.
机译：目的：自1982年以来，通过法国强制性报告系统报告的艾滋病患者的死亡率在法国西南部的阿基坦大区特别高。进行这项研究是为了确认阿基坦地区的患者死亡率高于法国其他地区，并确定其原因。设计：纳入了1982年1月至2005年6月之间报告的所有病例。使用Cox比例风险模型确定居住在阿基坦大区患者的相对死亡风险（RR）。考虑到1996年采用了高效抗逆转录病毒疗法（HAART），有两个时期被考虑在内。结果：自1982年以来，报告了60,212名AIDS患者。调整主要患者特征后，在引入HAART之前，生活在阿基坦地区的AIDS患者的死亡风险显着高于其他地区（RR = 1.12; IC95％= [1.06-1.18]）。 1996年之后，这种差异不再存在，甚至观察到相反的趋势（RR = 0.90; IC95％= [0.75-1.09]）。结论：阿基坦的总体死亡率较高是由于该地区1996年之前的死亡风险较高。一些假设可以解释此结果，例如较不详尽的通知或受试者的不同特征。在引入HAART之后观察到的相反趋势将在未来几年中得到检验。

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