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Early antiviral treatment fails to completely prevent herpes-related pain

机译：早期抗病毒治疗无法完全预防疱疹相关性疼痛

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Objectives: Antiviral therapy does not completely relieve herpes zoster (HZ)-related pain, including post-herpetic neuralgia (PHN). The 12-month longitudinal prospective observational ARIZONA study was conducted in primary care in France between November 20, 2006 and September 12, 2008. The ARIZONA study included data from 1358 patients 50years of age or more, presenting with acute eruptive HZ. This article focuses on the relationship between antiviral therapy and HZ-related pain in this large population. Patients and methods: Six hundred and forty-four family physicians (FPs) consecutively included all patients 50. years of age or more presenting with acute HZ in the eruptive phase. The FP documented every patient's demographic and medical characteristics, HZ characteristics, and prescribed drugs at inclusion, and the presence of HZ-related pain on day 15 and at months 1, 3, 6, 9, and 12. Results: One thousand two hundred and fifty-eight (92.6%) of the 1358 included patients (mean 67.7. years [SD 10.7]; 62.2% female patients) were given antiviral drugs. The prevalence of HZ-related pain was 43.6%, 27.0%, 11.7%, 8.7%, 7.4%, and 6.0%, on day15 and at months 1, 3, 6, 9, and 12, respectively. HZ-related pain was at least as frequent in patients treated by antiviral therapy within 72. hours following HZ-rash onset as in patients treated later or who did not receive antiviral treatment, and more frequent in patients whose diagnosis was made within 24. hours following HZ-rash onset. Conclusions: Antiviral therapy, even early, does not prevent HZ-related pain and PHN, probably because patients quickly identified and treated were those with severe forms and potentially at high risk of pain. Preventive strategies are thus needed.
机译：目的：抗病毒治疗不能完全缓解带状疱疹（HZ）相关的疼痛，包括疱疹后神经痛（PHN）。为期12个月的纵向前瞻性观察性ARIZONA研究于2006年11月20日至2008年9月12日在法国的初级保健机构中进行。ARIZONA研究纳入了1358名50岁以上的急性爆发性HZ患者的数据。本文重点介绍了在这一庞大人群中抗病毒治疗与HZ相关疼痛之间的关系。患者和方法：644位家庭医生（FPs）连续纳入了所有50.岁或以上在爆发期出现急性HZ的患者。 FP记录了每位患者的人口统计学和医学特征，HZ特征和所含处方药，以及在第15天以及第1、3、6、9和12个月时存在与HZ相关的疼痛。结果：12200 1358名患者中有58名（92.6％）接受了抗病毒药物治疗（平均67.7。年[SD 10.7]; 62.2％女性患者）。在第15天和第1、3、6、9和12个月，与HZ相关的疼痛的患病率分别为43.6％，27.0％，11.7％，8.7％，7.4％和6.0％。在HZ皮疹发作后72小时内，抗病毒治疗的患者与HZ相关疼痛的发生频率至少与后来治疗或未接受抗病毒治疗的患者相同，而在24小时内做出诊断的患者则更为常见在HZ-皮疹发作之后。结论：即使在早期，抗病毒治疗也不能预防与HZ相关的疼痛和PHN，这可能是因为快速识别和治疗的患者是重症患者，并且潜在的疼痛风险很高。因此，需要采取预防策略。

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