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首页> 外文期刊>Medecine et maladies infectieuses >Post-infectious immune suppression: A new paradigm of severe infections
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Post-infectious immune suppression: A new paradigm of severe infections

机译：感染后免疫抑制：重度感染的新范例

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摘要

Infectious diseases remain a major public health issue in both developing and developed countries. For instance, there is still a high rate of morbidity and mortality due to seasonal influenza outbreaks and severe bacterial sepsis, despite major advances in their prevention and treatment. It is now clear that severe influenza and bacterial infections promote susceptibility for superinfections worsening the prognosis. Various immune defects acquired during severe infection may result in complex immunosuppression and may affect both innate and adaptive components. Some animal models of these common clinical situations have demonstrated the increased susceptibility of infected hosts to secondary infectious insult and allowed assessing the regulatory mechanisms. Such pathophysiological advances may help create new immunomodulatory therapeutics for infected patients exposed to severe secondary sepsis.
机译：在发展中国家和发达国家，传染病仍然是主要的公共卫生问题。例如，尽管季节性流感爆发和严重的细菌败血症在预防和治疗方面取得了重大进展，但其发病率和死亡率仍然很高。现在很清楚，严重的流感和细菌感染会增加对超级感染的敏感性，从而使预后恶化。在严重感染期间获得的各种免疫缺陷可能导致复杂的免疫抑制，并可能影响先天和适应性成分。这些常见临床情况的一些动物模型表明，感染宿主对继发感染的敏感性增加，并允许评估其调控机制。这种病理生理学进展可能有助于为暴露于严重继发性败血症的感染患者创造新的免疫调节疗法。

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