...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Medecine et maladies infectieuses >Optimized clinical use of vancomycin, a prospective observational study in a Paris teaching hospital
【24h】

Optimized clinical use of vancomycin, a prospective observational study in a Paris teaching hospital

机译：优化万古霉素的临床使用，这是巴黎一家教学医院的前瞻性观察性研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

INTRODUCTION: Vancomycin is still the cornerstone of antibiotic therapy for patients with suspected or proven invasive methicillin resistant Staphylococcus aureus infections. However, clinical and pharmacodynamic studies underline that appropriate doses depend on the infection site, the patient's weight, his renal function, and the bacterial susceptibility. OBJECTIVE AND METHOD: In this prospective study made in a Paris teaching hospital, our two goals were to describe the modalities of infusion and serum concentration obtained during therapy, in our pediatrics and adults population. RESULTS: In our hospital, vancomycin was administered every eight hours in 83 % (97/102) of the cases and the doses used were 30 mg/kg per day in 67 % of cases (68/102). Serum trough levels reached 15 mcg/ml and 20 mcg/ml in 36 % and 18 % of cases respectively. Moreover, despite adequate doses, trough levels of 15 mcg/ml were obtained in only 40 % of cases. CONCLUSION: Vancomycin infusion use could be optimized, by defining optimal serum concentrations and monitoring made by a mobile team of infectious diseases specialists.
机译：简介：万古霉素仍然是疑似或经证实的侵袭性耐甲氧西林金黄色葡萄球菌感染患者抗生素治疗的基石。但是，临床和药效学研究强调适当的剂量取决于感染部位，患者的体重，肾脏功能和细菌敏感性。目的和方法：在巴黎一家教学医院进行的这项前瞻性研究中，我们的两个目标是描述在儿科和成人人群中输注的方式和在治疗期间获得的血清浓度。结果：在我们的医院中，有83％（97/102）的病例每8小时服用一次万古霉素，在67％（68/102）的病例中每天使用的剂量为30 mg / kg。在36％和18％的病例中，血清谷水平分别达到15mcg / ml和20mcg / ml。此外，尽管剂量足够，但仅在40％的病例中可达到15 mcg / ml的谷值。结论：可以通过确定最佳血清浓度和由传染病专家流动小组进行监测来优化万古霉素输注的使用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号