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首页> 外文期刊>Medecine et maladies infectieuses >Multiple organ failure and disseminated adenoviral infection
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Multiple organ failure and disseminated adenoviral infection

机译：多器官衰竭和弥漫性腺病毒感染

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BACKGROUND: Peripheral blood stem cell transplantation is a frequent option, especially for patients with hematological malignancies. CASE REPORTS: A first patient received this treatment for acute myeloblastic leukemia, the second for Richter's syndrome (follicular lymphoma). In both cases, allograft (unrelated donor, non myeloablative conditioning) was followed by graft versus host disease (GVH) requiring an immunosuppressive treatment. Respectively 15 and three months after graft, these two patients presented with multiple organ failure including very severe hepatic dysfunction. The diagnosis was made according to positive blood PCR, positive BAL, and hepatic histological findings. DISCUSSION: Adenoviruses, frequent in pediatrics, can be responsible for extremely severe infections among immunocompromised adults. T lymphocyte depletion plays a key role. CONCLUSION: Adenoviral infections can be fatal among immunocompromised patients. Diagnostic improvement should lead to early treatment, which however, remains to be clearly defined.
机译：背景：外周血干细胞移植是一种常见的选择，特别是对于血液系统恶性肿瘤患者。病例报告：第一例患者接受了急性粒细胞白血病的治疗，第二例患者接受了Richter综合征（滤泡性淋巴瘤）。在这两种情况下，同种异体移植（无关的供体，非清髓性调理）之后都是需要免疫抑制治疗的移植物抗宿主病（GVH）。这两例患者分别在移植后15和3个月出现多器官功能衰竭，包括非常严重的肝功能障碍。根据血液PCR阳性，BAL阳性和肝组织学检查结果进行诊断。讨论：儿科患者中常见的腺病毒可能是导致免疫功能低下的成年人极度严重感染的原因。 T淋巴细胞的耗竭起着关键作用。结论：免疫受损患者中腺病毒感染可能致命。诊断的改善应导致早期治疗，但是尚待明确定义。

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