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首页> 外文期刊>International journal of urology: official journal of the Japanese Urological Association >Interferon-related mental deterioration after craniotomy for removal of metastatic renal cancer.
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Interferon-related mental deterioration after craniotomy for removal of metastatic renal cancer.

机译：开颅手术后切除转移性肾癌后与干扰素相关的精神恶化。

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摘要

Interferon-related severe adverse events on the central nervous system are relatively rare, because interferon-alpha (INF-alpha) can not cross an intact blood-brain barrier. We experienced remarkable mental deterioration caused by INF-alpha administration in a 43-year-old man with renal cell carcinoma after surgical removal of a metastatic brain tumor. We detected a high concentration of INF-alpha in a cerebrospinal fluid sample, which was comparable to that in the serum at 24 h after the administration of INF-alpha; 5x10(6) IU i.m., suggesting that the blood-brain barrier was damaged somehow by the craniotomy. The mental deterioration improved shortly after discontinuation of the INF-alpha administration.
机译：与干扰素有关的中枢神经系统严重不良事件相对较少，因为干扰素-α（INF-alpha）不能穿过完整的血脑屏障。手术切除转移性脑瘤后，我们在43岁的肾细胞癌患者中因INF-α给药而导致了明显的精神恶化。我们在脑脊液样本中检测到高浓度的INF-α，这与INF-α给药后24小时的血清中的浓度相当。 5x10（6）IU i.m.，表明开颅手术以某种方式破坏了血脑屏障。停用INF-α药物后不久，精神恶化得到改善。

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