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Progress in recent study of anti-HBV natural products and extracts

机译：抗HBV天然产物及其提取物的最新研究进展

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Hepatitis B is a serious liver infectious disease, which remains a major public health problem worldwide. Though some effective treatments have been taken clinically, the therapeutic effects are moderate and suffer from the significant side effects and inevitable drug resistance. Therefore, the safer and more effective anti-HBV drugs are urgently required. Many natural products are well documented as their novel structures and potent bioactivity. Researchers worldwide, especially in China, have been exploring natural drugs against HBV. Some natural products with anti-HBV activities were found. Extracting and isolating pure compounds with anti-HBV bioactivity from natural resources are therefore a promising approach to discover and develop new drugs. Herein, we systematically elucidated the anti-HBV activity, chemical structure of some herb medicine extracts reported in literature recently. Furthermore, we compared the anti-HBV activities of these natural products, which would provide useful information for the pharmaceutical synthesis and evaluation.
机译：乙型肝炎是一种严重的肝感染性疾病，仍然是世界范围内的主要公共卫生问题。尽管已经在临床上采取了一些有效的治疗方法，但是治疗效果是中等的并且遭受明显的副作用和不可避免的耐药性。因此，迫切需要更安全，更有效的抗HBV药物。许多天然产物因其新颖的结构和强大的生物活性而得到了充分的文献记载。世界各地的研究人员，尤其是中国的研究人员，一直在探索抗HBV的天然药物。发现了一些具有抗乙肝病毒活性的天然产物。因此，从自然资源中提取和分离具有抗HBV生物活性的纯化合物是发现和开发新药物的有前途的方法。在本文中，我们系统地阐明了最近文献报道的某些草药提取物的抗HBV活性，化学结构。此外，我们比较了这些天然产物的抗HBV活性，这将为药物合成和评估提供有用的信息。

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