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首页> 外文期刊>journal of pharmaceutical innovation >Synthesis and Characterization of Naringenin-Loaded Chitosan-Dextran Sulfate Nanocarrier
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Synthesis and Characterization of Naringenin-Loaded Chitosan-Dextran Sulfate Nanocarrier

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Purpose The present study focused on synthesis and characterization of polymeric nanocarrier for the hydrophobic drug, naringenin (Nar), using chitosan (CS) and dextran sulfate (DS). Method CSDS-Nar and blank CSDS nanoparticles were prepared by complex coacervation technique. The nanoparticles were characterized by scanning electron microscopy (SEM), Fourier transform-infrared spectroscopy (FTIR), X-ray diffraction (XRD), and dynamic light scattering (DLS). Cytotoxicity evaluation of blank CSDS and CSDS-Nar was performed by MTT assay after 24-h incubation. Result The nanoparticles were observed to have spherical morphology. The size and zeta potential of the CSDS-Nar were similar to 337.2 +/- 48.27 nm and - 34.4 +/- 7.45 mV, respectively. The interactions between polymer and drug were confirmed by FTIR studies. The in vitro drug release studies showed that 80 of free naringenin was released rapidly at 36 h. On the other hand, 51 naringenin was released from CSDS-Nar at 36 h. MTT assay demonstrated that at higher dose, the cell viability of MCF-7 cells was 45 and 8 after CSDS and CSDS-Nar treatment, respectively. Conclusion Hence, the empirical findings of the study suggest that CSDS nanocarrier could be utilized as a promising and ideal carrier for delivery of naringenin and similar hydrophobic drugs to cancer cells.

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