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首页> 外文期刊>journal of pharmaceutical innovation >Modulating Gliclazide Release and Bioavailability Utilizing Multiparticulate Drug Delivery Systems
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Modulating Gliclazide Release and Bioavailability Utilizing Multiparticulate Drug Delivery Systems

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Purpose To formulate multiparticulate controlled-release alginate-gelatin (AL-GL) beads in order to modify gliclazide (GLZ) release rate. Methods AL-GL beads were prepared using different glutaraldehyde concentrations and dried using either air or freeze-drying method. For comparison, calcium alginate beads (AL-beads) were prepared at different temperatures. Drug incorporation efficiency, beads swelling, drug release rate, and kinetics in gradient conditions (USP Apparatus-4) were studied. Selected AL-GL beads, as a test formulation (T), were in-vivo compared with Diamicron (R) 80 mg conventional tablet (R). Results AL-beads curing temperature was inversely proportional to GLZ incorporation efficiency and directly proportional to beads swelling. GLZ release from AL-beads was slow in 0.1 N HCl and very fast in pH 7.4. In case of AL-GL beads, GLZ incorporation efficiency and swelling were inversely proportional to glutaraldehyde concentration. AL-GL beads showed zero-order release of GLZ for up to 11 h. Scanning electron microscope (SEM) images of the freeze-dried beads showed a highly porous surface. Differential scanning calorimetry (DSC) and Fourier transform infra-red (FT-IR) studies indicated an interaction between alginate and gelatin due to crosslinking, while FT-IR indicated the absence of chemical interaction with GLZ. The relative bioavailability (T/R) was 97.57, 138.34, and 143.53, for C-max, AUC(0-72), and AUC(0-infinity), respectively. T-max of T was significantly higher than R. Conclusion AL-GL beads could represent promising delivery systems for modulating GLZ release rate and minimizing the variation in its absorption.

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