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首页> 外文期刊>Cancer immunology, immunotherapy : >Cytokine production in peripheral blood cells of patients with differentiated thyroid cancer: elevated Th2/Th9 cytokine production before and reduced Th2 cytokine production after radioactive iodine therapy
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Cytokine production in peripheral blood cells of patients with differentiated thyroid cancer: elevated Th2/Th9 cytokine production before and reduced Th2 cytokine production after radioactive iodine therapy

机译：分化型甲状腺癌患者外周血细胞因子的产生：放射性碘治疗后Th2 / Th9细胞因子产生升高，Th2细胞因子产生减少

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摘要

Cytokines play a key role in the regulation of cells of the immune system and also have been implicated in the pathogenesis of malignant diseases. The aim of this study was to evaluate cytokine profiles in patients with differentiated thyroid cancer (DTC) before and 7 days after radioactive iodine (131-I) therapy. Cytokine levels were determined in supernatants obtained from phytohemagglutinin-stimulated whole blood cultures of 13 patients with DTC and 13 control subjects. The concentrations of selected cytokines: Th1-interferon gamma (IFN-gamma), interleukin 2 (IL-2) and tumor necrosis factor alpha (TNF-alpha); Th2-interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 13 (IL-13) and interleukin 10 (IL-10); Th9-interleukin-9 (IL-9); and Th17-interleukin 17 (IL-17A) were measured using multiplex cytokine detection systems for Human Th1/Th2/Th9/Th17/Th22. We have shown that peripheral blood cells of DTC patients produce significantly higher concentrations of Th2/Th9 cytokines (IL-5, IL-13 and IL-9) than control subjects. The 131-I therapy led to reduced secretion of Th2 cytokines (IL-4, IL-5 and IL-13). Despite this, the calculated cytokine ratios (Th1/Th2) in DTC patients before and 7 days after 131-I therapy were not different from those in healthy subjects. DTC patients have significantly higher concentrations of Th2/Th9 cytokines (IL-5, IL-13 and IL-9) than control subjects. There is no influence of hypothyroidism or stage of disease on cytokine production in DTC patients before 131-I therapy. The radioactive 131-I therapy leads to reduced secretion of Th2 cytokines (IL-4, IL-5 and IL-13). Additional studies are needed to determine the significance of these findings.
机译：细胞因子在免疫系统细胞的调节中起关键作用，并且还与恶性疾病的发病机理有关。这项研究的目的是评估放射性碘（131-I）治疗之前和之后7天的分化型甲状腺癌（DTC）患者的细胞因子谱。确定了从植物血凝素刺激的13名DTC患者和13名对照受试者的全血培养物中获得的上清液中的细胞因子水平。所选细胞因子的浓度：Th1-干扰素γ（IFN-γ），白介素2（IL-2）和肿瘤坏死因子α（TNF-alpha）; Th2-白介素4（IL-4），白介素5（IL-5），白介素13（IL-13）和白介素10（IL-10）; Th9-白介素9（IL-9）;使用针对人Th1 / Th2 / Th9 / Th17 / Th22的多重细胞因子检测系统测量了Th17和IL17白介素17（IL-17A）。我们已经显示，DTC患者的外周血细胞产生的Th2 / Th9细胞因子（IL-5，IL-13和IL-9）浓度明显高于对照组。 131-I治疗导致Th2细胞因子（IL-4，IL-5和IL-13）分泌减少。尽管如此，DTC患者在131-I治疗之前和之后的7天所计算的细胞因子比率（Th1 / Th2）与健康受试者没有差异。 DTC患者的Th2 / Th9细胞因子（IL-5，IL-13和IL-9）浓度明显高于对照组。在131-I治疗之前，甲状腺功能减退症或疾病阶段对DTC患者的细胞因子产生没有影响。放射性131-I治疗导致Th2细胞因子（IL-4，IL-5和IL-13）分泌减少。需要进行其他研究以确定这些发现的重要性。

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