Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors.

Zhou J; Brinckerhoff C; Lubert S; Yang K; Saini J; Hooke J; Mural R; Shriver C; Somiari S

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Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors.

机译：基质金属蛋白酶-1基因多态性分析在乳腺和恶性肿瘤中的表达。

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A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared to in situ breast cancer. MMP-1 2G insertion polymorphism in the invasive group also correlated significantly with the expression of MMP-1 and breast cancer prognostic markers HER2 and P53.

机译：基质金属蛋白酶-1启动子（MMP-1 2G）中的鸟嘌呤插入多态性与癌症的早期发作和侵袭性有关。我们确定了MMP-1 2G在乳腺疾病患者中对MMP-1表达和乳腺癌严重程度的作用。我们观察到不同疾病组之间的基因型分布没有显着差异。然而，与原位乳腺癌相比，非典型性导管增生中的MMP-1表达明显高于良性乳腺疾病和浸润性乳腺癌。侵袭性组的MMP-1 2G插入多态性也与MMP-1的表达以及乳腺癌预后标志物HER2和P53显着相关。

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《Cancer investigation》 |2011年第9期|共9页
作者
Zhou J; Brinckerhoff C; Lubert S; Yang K; Saini J; Hooke J; Mural R; Shriver C; Somiari S;
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正文语种 eng
中图分类肿瘤学;
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1. Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors. [J] . Zhou J, Brinckerhoff C, Lubert S, Cancer investigation . 2011,第9期

机译：基质金属蛋白酶-1基因多态性分析在乳腺和恶性肿瘤中的表达。
2. Immunohistochemical Study of Matrix Metalloproteinase 9 and Tissue Inhibitor of Matrix Metalloproteinase 1 in Benign and Malignant Breast Tissue - Strong Expression in Intraductal Carcinomas of the Breast [J] . E. Rahko, S. Kauppila, P. Paakko Tumour biology : . 2009,第5a6期

机译：乳腺良性和恶性组织中基质金属蛋白酶9和基质金属蛋白酶1组织抑制剂的免疫组织化学研究-在乳腺导管内癌中强表达
3. Functional Gene Polymorphism of Matrix Metalloproteinase-1 Is Associated with Benign Hyperplasia of Myo-and Endometrium in the Russian Population [J] . Elena B. Morosova, Alexei B. Chukhlovin, Natalia V. Kulagina, Genetic testing and molecular biomarkers . 2012,第9期

机译：基质金属蛋白酶-1的功能基因多态性与俄罗斯人口的子宫和子宫内膜良性增生相关。
4. Texture analysis of breast thermogram for differentiation of malignant and benign breast [C] . Sourav Pramanik, Debotosh Bhattacharjee, Mita Nasipuri International conference on advances in computing, communications and informatics . 2016

机译：乳房热成像的质地分析，可区分恶性和良性乳腺
5. Overexpression of the receptor tyrosine kinase EphA2 induces malignant transformation of benign mammary epithelia: Implication for increased cell survival and altered cellular adhesions in breast cancer. [D] . Zelinski, Daniel Paul. 2001

机译：受体酪氨酸激酶EphA2的过表达诱导了良性乳腺上皮的恶性转化：暗示增加细胞存活率和改变乳腺癌细胞粘附。
6. Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors [O] . Jing Zhou, Constance Brinckerhoff, Susan Lubert, -1

机译：基质金属蛋白酶1基因多态性分析和表达在良性和恶性乳腺肿瘤
7. Similar and Divergent Patterns in the Regulation of Matrix Metalloproteinase-1 (MMP-1) and Tissue Inhibitor of MMP-1 Gene Expression in Benign and Malignant Human Thyroid Cells1 [O] . S. Korem, M. B. Resnick, Z. Kraiem 1999

机译：在良性和恶性人甲状腺细胞中的基质金属蛋白酶-1（MMP-1）和MMP-1基因表达的组织抑制剂的调节中的类似和发散模式
8. Genetic Analysis of a Single Nucleotide Polymorphism in the Matrix Metalloproteinase 1 Promoter in Breast Cancer [R] . Brinckerhoff, C. B. 2003

机译：乳腺癌基质金属蛋白酶1启动子单核苷酸多态性的遗传分析

Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors.

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