Resumption of menses with initiation of letrozole after five years of amenorrhea on tamoxifen: caution needed when using tamoxifen followed by aromatase inhibitors.

Hargis JB; Nakajima ST

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Resumption of menses with initiation of letrozole after five years of amenorrhea on tamoxifen: caution needed when using tamoxifen followed by aromatase inhibitors.

机译：在他莫昔芬闭经五年后，开始用来曲唑恢复月经：在使用他莫昔芬及其后的芳香化酶抑制剂时要特别小心。

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BACKGROUND: Randomized trials in postmenopausal women have shown a benefit to substituting aromatase inhibitors for tamoxifen or using them sequentially following a full course of tamoxifen. The aromatase inhibitor letrozole has also been utilized for ovarian induction in premenopausal women. CASE REPORT: A premenopausal woman with early stage breast cancer became amenorrheic with adjuvant chemotherapy, and remained so during 5 years of daily tamoxifen. After discontinuing tamoxifen, laboratory studies confirmed an apparent postmenopausal state. Menses resumed following a 2-week course of letrozole. CONCLUSION: Aromatase inhibitors need to be used with caution in women who stop menstruating following adjuvant chemotherapy or tamoxifen.

机译：背景：绝经后妇女的随机试验显示，用芳香酶抑制剂替代他莫昔芬或在他莫昔芬整个疗程后依次使用它们是有好处的。芳香酶抑制剂来曲唑也已用于绝经前妇女的卵巢诱导。病例报告：患有早期乳腺癌的绝经前妇女在辅助化疗的情况下进入闭经，在他莫昔芬的5年内一直如此。停用他莫昔芬后，实验室研究证实了绝经后的一种明显状态。经来曲唑2周疗程后，月经恢复。结论：芳香化酶抑制剂在辅助化疗或他莫昔芬后停止月经的女性中应谨慎使用。

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《Cancer investigation》 |2006年第2期|共4页
作者
Hargis JB; Nakajima ST;
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正文语种 eng
中图分类肿瘤学;
关键词
Amenorrhea; Aromatase Inhibitors; Breast Neoplasms; Menstruation; Neoplasm Recurrence; Local; 闭经; 乳腺肿瘤; 月经; 肿瘤复发; 局部; 腈类; 三唑类;

机译：Amenorrhea;Aromatase Inhibitors;Breast Neoplasms;Menstruation;Neoplasm Recurrence;Local;闭经;乳腺肿瘤;月经;肿瘤复发;局部;腈类;三唑类;

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1. Resumption of menses with initiation of letrozole after five years of amenorrhea on tamoxifen: caution needed when using tamoxifen followed by aromatase inhibitors. [J] . Hargis JB, Nakajima ST Cancer investigation . 2006,第2期

机译：在他莫昔芬闭经五年后，开始用来曲唑恢复月经：在使用他莫昔芬及其后的芳香化酶抑制剂时要特别小心。
2. Cost-utility of adjuvant hormone therapies with aromatase inhibitors in post-menopausal women with breast cancer: upfront anastrozole, sequential tamoxifen-exemestane and extended tamoxifen-letrozole. [J] . Skedgel C, Rayson D, Dewar R, The Breast : . 2007,第3期

机译：乳腺癌绝经后妇女使用芳香酶抑制剂辅助激素治疗的成本效用：前期阿那曲唑，序贯他莫昔芬-依斯美坦和延长他莫昔芬-来曲唑。
3. Bone mineral density in breast cancer patients treated with adjuvant letrozole, tamoxifen, or sequences of letrozole and tamoxifen in the BIG 1-98 study (SAKK 21/07) [J] . ZamanK., ThürlimannB., HuoberJ., Annals of oncology: official journal of the European Society for Medical Oncology . 2012,第6期

机译：在BIG 1-98研究中，接受来曲唑，他莫昔芬或来曲唑和他莫昔芬序列治疗的乳腺癌患者的骨矿物质密度（SAKK 21/07）
4. Aromatase Inhibitors in Prevention - Data from the ATAC (Arimidex, Tamoxifen Alone or in Combination) Trial and the Design of IBIS-II (the Second International Breast Cancer Intervention Study) [C] . Jack Cuzick International Society of Cancer Chemoprevention . 2003

机译：预防芳族酶抑制剂 - 来自ATAC（ARIMIDEX，Tamoxifen单独或组合或组合的数据）的数据和IBIS-II的设计（第二次国际乳腺癌干预研究）
5. Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance [O] . Sarah A. Dabydeen, Keunsoo Kang, Edgar S. Díaz-Cruz, -1

机译：ER和过表达芳香化酶的小鼠乳腺前肿瘤中他莫昔芬和来曲唑反应的比较确定了与他莫昔芬抗性相关的免疫相关基因标志
6. Bone mineral density in breast cancer patients treated with adjuvant letrozole, tamoxifen, or sequences of letrozole and tamoxifen in the BIG 1-98 study (SAKK 21/07) [O] . Zaman, K., Thürlimann, B., Huober, J., 2017

机译：BIG 1-98研究中接受来曲唑，他莫昔芬或来曲唑和他莫昔芬序列治疗的乳腺癌患者的骨矿物质密度（SAKK 21/07）

Resumption of menses with initiation of letrozole after five years of amenorrhea on tamoxifen: caution needed when using tamoxifen followed by aromatase inhibitors.

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