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首页> 外文期刊>Cancer letters >MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells.
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MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells.

机译：MAC相关的线粒体途径在人肝癌HepG2细胞中的oroxylin-A诱导的细胞凋亡中。

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摘要

Oroxylin A is a flavonoid isolated from the root of Scutellaria baicalensis Georgi. Our previous work demonstrated that the anti-tumor activity of oroxylin A was mainly attributed to its apoptosis inducing effect in cells. The present study explores the exact molecular mechanism of oroxylin A-induced apoptosis in tumor cells. We showed that oroxylin A-induced apoptosis in HepG2 cells was achieved through mitochondrial pathway. We also investigated which mitochondrial channels, PTP or MAC or both, were involved in the permeabilization of the mitochondrial outer membrane after treatment with oroxylin A. The results showed that oroxylin A-induced apoptosis in a PTP-independent manner; therefore, we focused our attention on MAC. As Bax is an essential constituent of MAC in certain systems, we examined the activation, subcellular location, oligomeric structure of Bax in HepG2 cells treated with oroxylin A. Moreover, our results showed that overexpression of Bcl-2 inhibited oroxylin A-induced apoptosis. In summary, we have demonstrated that opening of MAC, but not PTP, played a key role in oroxylin A-induced activation of mitochondrial apoptotic pathway in HepG2 cells.
机译：Oroxylin A是从黄cut根中提取的黄酮。我们以前的工作表明，木素A的抗肿瘤活性主要归因于其在细胞中的凋亡诱导作用。本研究探讨了奥昔林A诱导肿瘤细胞凋亡的确切分子机制。我们表明，通过线粒体途径实现了Oroxylin A诱导的HepG2细胞凋亡。我们还研究了在用木犀草素A处理后，线粒体外膜的通透性涉及哪些线粒体通道，PTP或MAC或两者都参与。因此，我们将注意力集中在MAC上。由于Bax在某些系统中是MAC的重要组成部分，因此我们检查了用Oroxylin A处理的HepG2细胞中Bax的活化，亚细胞定位和寡聚结构。此外，我们的结果表明Bcl-2的过表达抑制了Oroxylin A诱导的细胞凋亡。总而言之，我们已经证明，MAC的打开而不是PTP的开放在Oroxylin A诱导的HepG2细胞线粒体凋亡途径活化中起关键作用。

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