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首页> 外文期刊>Cancer letters >Microsatellite instability with promoter methylation and silencing of hMLH1 can regionally occur during progression of gastric carcinoma.
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Microsatellite instability with promoter methylation and silencing of hMLH1 can regionally occur during progression of gastric carcinoma.

机译：具有启动子甲基化和hMLH1沉默的微卫星不稳定性可能在胃癌进展期间局部发生。

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摘要

Microsatellite instability (MSI) is known to result from inactivation of mismatch repair genes largely by promoter methylation. However, the methylation usually accumulates time-dependently. To know whether MSI can be acquired later in tumorigenesis, we examined intratumoral heterogeneity of MSI and promoter methylation of hMLH1 after immunohistochemical screening for heterogeneous expression of hMLH1 in 55 cases of gastric carcinomas. We demonstrated for the first time that MSI-H can develop from MSI-L or the absence of MSI due to time-dependent accumulation of DNA methylation during progression of early-stage gastric carcinomas. The resultant replication errors may play a role in enhancing invasive activity.
机译：已知微卫星不稳定性（MSI）主要是由于启动子甲基化导致失配修复基因失活所致。但是，甲基化通常依赖时间累积。为了了解是否可以在肿瘤发生的后期获得MSI，我们在55例胃癌患者的免疫组化筛选后，检查了MSI的肿瘤内异质性和hMLH1的启动子甲基化。我们首次证明，由于早期胃癌进展期间DNA甲基化的时间依赖性积累，MSI-H可以从MSI-L发育或不存在MSI。产生的复制错误可能在增强侵袭活性中起作用。

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