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首页> 外文期刊>Molecular Biology >Replication protein A as a major eukaryotic single-stranded DNA-binding protein and its role in DNA repair
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Replication protein A as a major eukaryotic single-stranded DNA-binding protein and its role in DNA repair

机译：复制蛋白A作为一种主要的真核单链DNA结合蛋白及其在DNA修复中的作用

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摘要

Replication protein A (RPA) is a key regulator of eukaryotic DNA metabolism. RPA is a highly conserved heterotrimeric protein and contains multiple oligonucleotide/oligosaccharide-binding folds. The major RPA function is binding to single-stranded DNA (ssDNA) intermediates forming in DNA replication, repair, and recombination. Although binding ssDNA with high affinity, RPA can rapidly diffuse along ssDNA and destabilizes the DNA secondary structure. A highly dynamic RPA binding to ssDNA allows other proteins to access ssDNA and to displace RPA from the RPA-ssDNA complex. As has been shown recently, RPA in complex with ssDNA is posttranslationally modified in response to DNA damage. These modifications modulate the RPA interactions with its protein partners and control the DNA damage signaling pathways. The review considers up-to-date data on the RPA function as an active coordinator of ssDNA intermediate processing within DNA metabolic pathways, DNA repair in particular.
机译：复制蛋白A（RPA）是真核DNA代谢的关键调节剂。 RPA是高度保守的异三聚体蛋白，包含多个寡核苷酸/寡糖结合折叠。 RPA的主要功能是与DNA复制，修复和重组中形成的单链DNA（ssDNA）中间体结合。尽管以高亲和力结合ssDNA，但RPA可以沿ssDNA迅速扩散并破坏DNA二级结构的稳定性。与ssDNA的高度动态RPA结合使其他蛋白质可以访问ssDNA并从RPA-ssDNA复合物中置换RPA。如最近所显示的，响应于DNA损伤，与ssDNA复合的RPA被翻译后修饰。这些修饰调节RPA及其蛋白伴侣的相互作用，并控制DNA损伤信号传导途径。审查认为RPA功能的最新数据是DNA代谢途径中特别是DNA修复途径中ssDNA中间加工的积极协调者。

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