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首页> 外文期刊>Molecular and Cellular Biochemistry: An International Journal for Chemical Biology >Denervation provokes greater reductions in insulin-stimulated glucose transport in muscle than severe diabetes
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Denervation provokes greater reductions in insulin-stimulated glucose transport in muscle than severe diabetes

机译：与严重的糖尿病相比，神经支配引起的胰岛素刺激的葡萄糖葡萄糖转运减少更多

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摘要

We have examined the independent and combined effects of insulin insufficiency (streptozotocin (STZ)-induced diabetes, 85 mg/kg i.p.) and reduced muscle activity (denervation) (7 days) on basal, insulin-stimulated and contraction-stimulated glucose transport in rat muscles (soleus, red and white gastrocnemius). There were four treatments: control, denervated, diabetic, and denervated + diabetic muscles. Contraction-stimulated glucose transport was lowered (approx 50%) (p < 0.05) to the same extent in all experimental groups. In contrast, there was a much smaller reduction insulin-stimulated glucose transport in muscles from diabetic animals (18-24% reduction, p < 0.05) than in denervated muscles (40-60% reduction, p < 0.05) and in denervated + diabetic muscles (40-60% reduction, p < 0.05). GLUT-4 mRNA reduction was greatest in denervated + diabetic muscles (approx-75%, p < 0.05). GLUT-4 protein was decreased (p < 0.05) to a similar extent in all three experimental conditions(approx -30-40%). In conclusion, (1) muscle inactivity (denervation) and STZ-induced diabetes had similar effects on reducing contraction-stimulated glucose transport, but (2) muscle inactivity (denervation), rather than severe diabetes, produced a 2-fold greater impairment in skeletal muscle insulin-stimulated glucose transport.
机译：我们已经研究了胰岛素功能不全（链脲佐菌素（STZ）诱导的糖尿病，85 mg / kg ip）和肌肉活动减少（去神经）（7天）对基础，胰岛素刺激和收缩刺激的葡萄糖转运的独立和综合影响。大鼠肌肉（比目鱼肌，红色和白色腓肠肌）。有四种治疗方法：对照，神经肌肉，糖尿病和神经肌肉+糖尿病肌肉。在所有实验组中，收缩刺激的葡萄糖转运均降低（约50％）（p <0.05）。相比之下，糖尿病动物肌肉中的胰岛素刺激的葡萄糖转运减少幅度要小（减少18-24％，p <0.05），而神经肌肉缺损的患者（减少40-60％，p <0.05）和神经肌肉+糖尿病肌肉（减少40-60％，p <0.05）。 GLUT-4 mRNA的减少在神经失常+糖尿病肌中最大（约75％，p <0.05）。在所有三个实验条件下（约-30-40％），GLUT-4蛋白均降低（p <0.05）至相似的程度。总之，（1）肌肉不活动（去神经支配）和STZ诱导的糖尿病在减少收缩刺激的葡萄糖转运方面具有相似的作用，但是（2）肌肉不活动（去神经支配）而不是严重的糖尿病会导致肌肉损伤增加2倍。骨骼肌胰岛素刺激的葡萄糖转运。

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