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首页> 外文期刊>Molecular and Cellular Endocrinology >Circulating gonadotropins and ovarian adiponectin system are modulated by acupuncture independently of sex steroid or beta-adrenergic action in a female hyperandrogenic rat model of polycystic ovary syndrome
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Circulating gonadotropins and ovarian adiponectin system are modulated by acupuncture independently of sex steroid or beta-adrenergic action in a female hyperandrogenic rat model of polycystic ovary syndrome

机译：在多囊卵巢综合征女性高雄激素大鼠模型中，针刺可独立于性类固醇或β-肾上腺素能来调节循环性促性腺激素和卵巢脂联素系统

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Acupuncture with combined manual and low-frequency electrical stimulation, or electroacupuncture (EA), reduces endocrine and reproductive dysfunction in women with polycystic ovary syndrome (PCOS), likely by modulating sympathetic nerve activity or sex steroid synthesis. To test this hypothesis, we induced PCOS in rats by prepubertal implantation of continuous-release letrozole pellets (200 mu g/day) or vehicle. Six weeks later, rats were treated for 5-6 weeks with low-frequency EA 5 days/week, subcutaneous injection of 17 beta-estradiol (2.0 mu g) every fourth day, or a beta-adrenergic blocker (propranolol hydrochloride, 0.1 mg/kg) 5 days/week. Letrozole controls were handled without needle insertion or injected with sesame oil every fourth day. Estrous cyclicity, ovarian morphology, sex steroids, gonadotropins, insulin-like growth factor I, bone mineral density, and gene and protein expression in ovarian tissue were measured. Low-frequency EA induced estrous-cycle changes, decreased high levels of circulating luteinizing hormone (LH) and the LH/follicle-stimulating hormone (FSH) ratio, decreased high ovarian gene expression of adiponectin receptor 2, and increased expression of adiponectin receptor 2 protein and phosphorylation of ERK1/2. EA also increased cortical bone mineral density. Propranolol decreased ovarian expression of Foxo3, Srd5al, and Hif1a. Estradiol decreased circulating LH, induced estrous cycle changes, and decreased ovarian expression of Adipor1, Foxo3, and Pik3r1. Further, total bone mineral density was higher in the letrozole-estradiol group. Thus, EA modulates the circulating gonadotropin levels independently of sex steroids or beta-adrenergic action and affects the expression of ovarian adiponectin system. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：针刺结合手动和低频电刺激或电针（EA）可以减轻多囊卵巢综合征（PCOS）妇女的内分泌和生殖功能障碍，这可能是通过调节交感神经活动或性类固醇合成来实现的。为了验证这一假设，我们通过青春期前连续释放来曲唑微丸（200μg /天）或赋形剂诱导了大鼠PCOS。六周后，每隔5天/周用低频EA治疗大鼠5-6周，每四天皮下注射17种β-雌二醇（2.0μg）或β-肾上腺素能阻滞剂（盐酸普萘洛尔，0.1 mg / kg）5天/周。每四天处理一次来曲唑对照，不插入针头或注射芝麻油。测量了卵巢的发情周期，卵巢形态，性类固醇，促性腺激素，胰岛素样生长因子I，骨矿物质密度以及基因和蛋白质表达。低频EA诱导发情周期变化，循环黄体生成激素（LH）和促LH /卵泡刺激素（FSH）的高水平降低，脂联素受体2的高卵巢基因表达降低，脂联素受体2的表达升高蛋白和ERK1 / 2的磷酸化。 EA还增加了皮质骨矿物质密度。普萘洛尔降低Foxo3，Srd5al和Hif1a的卵巢表达。雌二醇减少循环LH，诱导发情周期变化，并降低Adipor1，Foxo3和Pik3r1的卵巢表达。此外，来曲唑-雌二醇组的总骨矿物质密度更高。因此，EA独立于性类固醇或β-肾上腺素能调节循环性促性腺激素水平，并影响卵巢脂联素系统的表达。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

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