The structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation.

Rapti A; Trangas T; Samiotaki M; Ioannidis P; Dimitriadis E; Meristoudis C; Veletza S; Courtis N

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The structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation.

机译：哺乳动物的poly（A）聚合酶-αmRNA的5'非翻译区的结构表明翻译调控的机制。

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Poly(A)polymerase-alpha (PAPOLA) has been the most extensively investigated mammalian polyadenylating enzyme, mainly in regard to its multifaceted post-translational regulation. The possibility of translational regulation of this enzyme was addressed. The transcription start site was mapped and two uORFs, highly conserved among several species, were identified in the 211-bp long, GC-rich, 5' UTR of the PAPOLA mRNA. Mutation of the 5' proximal AUG resulted in increased translational efficiency of the adjacent coding sequence, whereas no significant effect was observed after mutation of the second AUG. These observations imply that translational regulation is among the conserved mechanisms regulating PAPOLA expression.

机译：聚（A）聚合酶-α（PAPOLA）是研究最广泛的哺乳动物聚腺苷酸化酶，主要是关于其多方面的翻译后调控。解决了该酶翻译调控的可能性。绘制了转录起始位点，并在PAPOLA mRNA的211 bp长，富含GC的5'UTR中鉴定了两个物种中高度保守的两个uORF。 5'近端AUG的突变导致相邻编码序列的翻译效率提高，而第二个AUG突变后未观察到明显的作用。这些观察结果暗示翻译调节是调节PAPOLA表达的保守机制之一。

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《Molecular and Cellular Biochemistry: An International Journal for Chemical Biology》 |2010年第2期|共6页
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Rapti A; Trangas T; Samiotaki M; Ioannidis P; Dimitriadis E; Meristoudis C; Veletza S; Courtis N;
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中图分类细胞生物化学;
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1. The structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation. [J] . Rapti A, Trangas T, Samiotaki M, Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2010,第1a2期

机译：哺乳动物的poly（A）聚合酶-αmRNA的5'非翻译区的结构表明翻译调控的机制。
2. Efficient cap-dependent translation of mammalian mRNAs with long and highly structured 5'-untranslated regions in vitro and in vivo [J] . S E Dmitriev D E Andreev Z V Adyanova I M Terenin I N Shatsky Molecular Biology . 2009,第1期

机译：在体外和体内有效的具有长且高度结构化的5'-非翻译区的哺乳动物mRNAs的帽依赖性翻译
3. Efficient Cap-Dependent Translation of Mammalian mRNAs with Long and Highly Structured 5'-Untranslated Regions in Vitro and in Vivo [J] . S. E. Dmitriev, D. E. Andreev, Z. V. Adyanova Molecular Biology . 2009,第1期

机译：高效的帽依赖翻译的哺乳动物mRNAs的长和高度结构化的5'-非翻译区的体内和体外
4. Constrained RNA Structural Alignment: Algorithms and Application to Motif Detection in the Untranslated Regions of Trypanosoma brucei mRNAs [C] . Mugdha Khaladkar, Vivian Bellofatto, Jason T. L. Wang, IEEE International Symposium on Bioinformatics and Bioengineering . 2007

机译：受约束的RNA结构对准：算法和在胰蛋白酶瘤的未翻译区域中的基序检测的应用
5. The molecular architecture of translational regulatory elements within the 5' untranslated region of the chloroplast psbC mRNA in Chlamydomonas reinhardtii. [D] . Rahim, Mir Munir Ahmed. 2003

机译：reinhardtii衣藻叶绿体psbC mRNA 5'非翻译区内翻译调控元件的分子结构。
6. DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions [O] . Markus Sauer, Stefan A. Juranek, James Marks, -1

机译：DHX36防止未翻译区域中具有G4结构的翻译无效mRNA的积累
7. Proteins binding to 5' untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells. [O] . Stripecke, R, Oliveira, C C, McCarthy, J E, 1994

机译：结合5'非翻译区位点的蛋白质：在人类和酵母细胞中翻译调节mRNA的一般机制。

The structure of the 5'-untranslated region of mammalian poly(A) polymerase-alpha mRNA suggests a mechanism of translational regulation.

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