A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells

ShenK.; SunL.; ZhangH.; XuY.; QianX.; LuY.; LiQ.; NiL.; LiuJ.

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A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells

机译：新型Amonafide类似物7c在人Hela宫颈癌细胞中诱导ROS介导的溶酶体-线粒体途径

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In this study, a novel naphthalimide derivative 7c was designed which is topo II inhibiting though owning weak DNA binders. It was shown that 7c could induce cancer cells apoptosis and have less cytotoxicity in normal human cell. Further investigations on Hela cells revealed that 7c could also induce ROS generation, lysosome rupture as well as cathepsin B release. Subsequent mitochondrial damages including mitochondrial membrane permeabilization and the release of cytochrome c were also found in 7c when treating with Hela cells. According to our data, 7c may act as a lead compound for potential anticancer drugs. The idea of naphthalimides modification may also provide a novel strategy for naphthalimides design.

机译：在这项研究中，设计了一种新颖的萘二甲酰亚胺衍生物7c，尽管它具有弱的DNA结合剂，但它对topo II具有抑制作用。结果表明7c可以诱导癌细胞凋亡，对正常人细胞的细胞毒性较小。对Hela细胞的进一步研究表明7c还可以诱导ROS产生，溶酶体破裂以及组织蛋白酶B释放。用Hela细胞处理后，在7c中还发现了随后的线粒体损伤，包括线粒体膜通透性和细胞色素c的释放。根据我们的数据，7c可能充当潜在抗癌药物的先导化合物。萘二甲酰亚胺改性的想法也可以为萘二甲酰亚胺设计提供新颖的策略。

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《Cancer letters》 |2013年第2期|共10页
作者
ShenK.; SunL.; ZhangH.; XuY.; QianX.; LuY.; LiQ.; NiL.; LiuJ.;
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正文语种 eng
中图分类肿瘤学;
关键词
7c; Apoptosis; Lysosomes; Mitochondrion; Oxidative stress;

机译：7c;细胞凋亡;溶酶体;线粒体;氧化应激;

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1. A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells [J] . ShenK., SunL., ZhangH., Cancer letters . 2013,第2期

机译：新型Amonafide类似物7c在人Hela宫颈癌细胞中诱导ROS介导的溶酶体-线粒体途径
2. Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway [J] . Zhao Xinwei, Tao Xufeng, Xu Lina, Molecules . 2016,第6期

机译：薯os皂甙通过ROS介导的DNA损伤和线粒体信号通路诱导人宫颈癌Hela和SiHa细胞凋亡。
3. Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway [J] . Xinwei Zhao, Xufeng Tao, Lina Xu, Molecules . 2016,第6期

机译：薯os皂甙通过ROS介导的DNA损伤和线粒体信号通路诱导人宫颈癌Hela和SiHa细胞凋亡。
4. M2-A, A Novel Amonafide Analogue, Induces Apoptosis and G2-M Arrest via Decreasing Topoisomerase LIa Activity and Inhibits PI3K/Akt Pathway on HL60 Cells [C] . The 12th Asian Pacific Confederation of Chemical Engineering Congress(第十二届亚太化工联盟大会暨化工展览会)论文集 . 2008

机译：M2-A，一种新颖的阿莫那肽类似物，通过降低拓扑异构酶LIa活性诱导HL60细胞凋亡和G2-M逮捕并抑制PI3K / Akt途径。
5. IMMUNOLOGY OF SQUAMOUS CELL CARCINOMA OF THE HUMAN UTERINE CERVIX. [D] . DINI, MORTEZA MESHKATOD. 1980

机译：人子宫宫颈鳞状细胞癌的免疫学
6. Correction: Zhao X.W. et al. Dioscin Induces the Apoptosis of Human Cervical Carcinoma HeLa and SiHa Cells Through ROS-mediated DNA Damage Cell Cycle Arrest and Mitochondrial Signaling Pathways. Molecules 2016 21 730 [O] . Xinwei Zhao, Xufeng Tao, Lina Xu, 2020

机译：校正：ZhaoX.W.等。薯os皂素通过ROS介导的DNA损伤细胞周期阻滞和线粒体信号传导途径诱导人宫颈癌Hela和SiHa细胞凋亡。分子201621730
7. Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway [O] . Xinwei Zhao, Xufeng Tao, Lina Xu, 2016

机译：Dioscin通过ROs介导的DNa损伤和线粒体信号通路诱导人宫颈癌HeLa和siHa细胞凋亡

A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells

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