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首页> 外文期刊>Molecular and cellular neurosciences >Differing phagocytic capacities of accessory and main olfactory ensheathing cells and the implication for olfactory glia transplantation therapies
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Differing phagocytic capacities of accessory and main olfactory ensheathing cells and the implication for olfactory glia transplantation therapies

机译：辅助和主要嗅鞘细胞吞噬能力的差异及其对嗅神经胶质细胞移植治疗的意义

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The rodent olfactory systems comprise the main olfactory system for the detection of odours and the accessory olfactory system which detects pheromones. In both systems, olfactory axon fascicles are ensheathed by olfactory glia, termed olfactory ensheathing cells (OECs), which are crucial for the growth and maintenance of the olfactory nerve. The growth-promoting and phagocytic characteristics of OECs make them potential candidates for neural repair therapies such as transplantation to repair the injured spinal cord. However, transplanting mixed populations of glia with unknown properties may lead to variations in outcomes for neural repair. As the phagocytic capacity of the accessory OECs has not yet been determined, we compared the phagocytic capacity of accessory and main OECs in vivo and in vitro. In normal healthy animals, the accessory OECs accumulated considerably less axon debris than main OECs in vivo. Analysis of freshly dissected OECs showed that accessory OECs contained 20% less fluorescent axon debris than main OECs. However, when assayed in vitro with exogenous axon debris added to the culture, the accessory OECs phagocytosed almost 20% more debris than main OECs. After surgical removal of one olfactory bulb which induced the degradation of main and accessory olfactory sensory axons, the accessory OECs responded by phagocytosing the axon debris. We conclude that while accessory OECs have the capacity to phagocytose axon debris, there are distinct differences in their phagocytic capacity compared to main OECs. These distinct differences may be of importance when preparing OECs for neural transplant repair therapies. (C) 2015 Elsevier Inc. All rights reserved.
机译：啮齿动物嗅觉系统包括用于检测气味的主要嗅觉系统和用于检测信息素的辅助嗅觉系统。在这两个系统中，嗅轴突束被嗅神经胶质细胞包裹，被称为嗅鞘细胞（OEC），这对于嗅神经的生长和维持至关重要。 OEC的促生长和吞噬特性使其成为神经修复疗法（例如移植修复受损脊髓的神经疗法）的潜在候选者。但是，移植特性未知的混合胶质细胞可能会导致神经修复结果的变化。由于尚未确定辅助OEC的吞噬能力，​​因此我们比较了体内和体外辅助OEC和主要OEC的吞噬能力。在正常健康的动物中，副OEC在体内积聚的轴突碎片少于主要OEC。对新鲜解剖的OEC的分析表明，附属OEC的荧光轴突碎片比主要OEC少20％。但是，在体外分析中，在培养物中添加了外源轴突碎片时，副OEC吞噬的碎片几乎比主要OEC多了20％。在手术切除引起主要和副嗅觉感觉轴突降解的一个嗅球后，副OEC通过吞噬轴突碎片作出反应。我们得出的结论是，虽然辅助OEC具有吞噬细胞轴突碎片的能力，但与主要OEC相比，它们的吞噬能力却存在明显差异。当准备用于神经移植修复疗法的OEC时，这些明显的差异可能很重要。 （C）2015 Elsevier Inc.保留所有权利。

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